Design and Evaluation of a Double-Gate Tunnel Field Effect Transistor for the Detection of Breast Cancer Cells

Abstract:

This research paper investigates the application of a Double Gate (DG) Tunnel Field-Effect Transistor (DG-TFET) for the detection of cell lines derived from breast cancer tissue, namely Hs578T, MDA-MB-231, MCF-7, and T47D. The device incorporates two nanocavities positioned beneath the two gate electrodes, significantly enhancing detection capabilities. The study emphasizes the differentiation between healthy non-tumorigenic cells (MCF-10A) and breast cancer-derived cell lines by incorporating gate engineering into the TFET. Furthermore, the research explores the impact of changes in dielectric values specific to different breast malignant cell types on the biosensor's detection capabilities. Additionally, the investigation delves into the influence of variations in device geometry, including cavity dimensions and dielectric layer thickness, on critical parameters such as drain current sensitivity, transconductance sensitivity, and ION/IOFF sensitivity. Sensitivity analysis concerns drive current, ION/IOFF ratio, threshold voltage (Vth), and transconductance. The structural design of the device is tailored to facilitate array-based diagnosis and screening of cell lines derived from breast cancer tissue. This design offers several advantages, including a simplified transduction process, compatibility with CMOS processes, cost-effectiveness, reproducibility, and adjustable electrical responses. The researchers employed ATLAS, a two-dimensional (2D) device simulator from Silvaco, to model and define the device structure. The numerical simulations validate the device's performance, demonstrating favorable ON-OFF transition profiles.

• Periodical: Journal of Biomimetics, Biomaterials and Biomedical Engineering (Volume 64)
• Pages: 105-113
• DOI: https://doi.org/10.4028/p-nKu9ik
• Online since: April 2024
• Authors: P. Vimala*, Salman Saleem, T.S. Arun Samuel
• Keywords: Drain Current, Electric Field, Hafnium Oxide, Tumorigenic Cells, Tunnel Field Effect Transistor

References

[1] Y. Zhang, M. Li, X. Gao, Y. Chen, and T. Liu, Nanotechnology in cancer diagnosis: Progress, challenges and opportunities. J. Hematol. Oncol., 12 (2019) 1–13.

DOI: 10.1186/s13045-019-0833-3

[2] J. G. Elmore, M. B. Barton, V. M. Moceri, S. Polk, P. J. Arena, and S. W. Fletcher, Ten-year risk of false positive screening mammograms and clinical breast examinations, New England J. Med., 338 (1998) 1089–1096.

DOI: 10.1056/nejm199804163381601

[3] P. Skaane, S. Hofvind, and A. Skjennald, Randomized trial of screen-film versus full-field digital mammography with soft-copy reading in population-based screening program: Follow-up and final results of Oslo II study, Radiology, 244 (2007) 708–717.

DOI: 10.1148/radiol.2443061478

[4] P. A. Carney et al., Individual and combined effects of age, breast density, and hormone replacement therapy use on the accuracy of screen- ing mammography, Ann. Internal Med., 138 (2003) 168–175.

DOI: 10.7326/0003-4819-138-3-200302040-00008

[5] S. J. Lord et al., A systematic review of the effectiveness of magnetic resonance imaging (MRI) as an addition to mammography and ultra- sound in screening young women at high risk of breast cancer, Eur. J. Cancer, 43 (2007) 1905–1917.

DOI: 10.1016/j.ejca.2007.06.007

[6] M. Al-Foheidi, M. M. Al-Mansour, and E. M. Ibrahim, Breast cancer screening: Review of benefits and harms, and recommendations for developing and low-income countries, Med. Oncol., 30 (2013) 471.

DOI: 10.1007/s12032-013-0471-5

[7] E. C. Fear, P. M. Meaney, and M. A. Stuchly, Microwaves for breast cancer detection. IEEE Potentials, 22 (2003) 12–18.

DOI: 10.1109/mp.2003.1180933

[8] M. Säbel and H. Aichinger, Recent developments in breast imaging, Phys. Med. Biol., 41(1996) 315–368.

DOI: 10.1088/0031-9155/41/3/001

[9] G. Bindu, S. Abraham, C. K. Aanandan, and K. T. Mathew, Microwave characterization of female human breast tissues, in Proc. 9th Eur. Conf. Wireless Technol., (2006) 123–126.

DOI: 10.1109/ecwt.2006.280450

[10] U. M. Pal et al., Optical spectroscopy-based imaging techniques for the diagnosis of breast cancer: A novel approach, Appl. Spectrosc. Rev., 55 (2020) 778–804.

[11] Vimala, P., Krishna, L.L. & Sharma, S.S. TFET Biosensor Simulation and Analysis for Various Biomolecules. Silicon 14 (2022) 7933–7938.

DOI: 10.1007/s12633-021-01570-x

[12] E. C. Fear, X. Li, S. C. Hagness, and M. A. Stuchly, Confocal microwave imaging for breast cancer detection: Localization of tumors in three dimensions, IEEE Trans. Biomed. Eng., 49 (2002) 812–822.

DOI: 10.1109/tbme.2002.800759

[13] S. Chaudhary, R. Mishra, A. Swarup, and J. Thomas, Dielectric properties of normal and malignant human breast tissues at radio wave and microwave frequencies, Indian J. Biochem. Biophys., 21 (1981) 76–79.

[14] J. E. Jeyanthi, T. S. Arun Samuel, A. Sharon Geege & Vimala P, A Detailed Roadmap from Single Gate to Heterojunction TFET for Next Generation Devices, Silicon, 14 (2022) 3185–3197.

DOI: 10.1007/s12633-021-01148-7

[15] R. Vishnoi and M. J. Kumar, Compact analytical drain current model of gate-all-around nanowire tunneling FET, IEEE Trans. Electron Devices, 61(2014) 2599–2603.

DOI: 10.1109/ted.2014.2322762

[16] G.H Nayana, P.Vimala, M Karthigai Pandian and T.S. Arun Samuel, Simulation insights of a new Dual Gate Graphene Nano-Ribbon Tunnel Field-Effect Transistors for THz applications, Diamond & Related Materials, 121, (2022) 1-7.

DOI: 10.1016/j.diamond.2021.108784

[17] S. Singh and S. Singh, Dopingless Negative Capacitance Ferroelectric TFET for Breast Cancer Cells Detection: Design and Sensitivity Analysis, in IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 69 (2022) 1120-1129.

DOI: 10.1109/tuffc.2021.3136099

[18] S. Singh and S. Singh, Analog/RF performance projection of ultra-steep Si doped HfO2 based negative capacitance electrostatically doped TFET: A process variation resistant design, Silicon 14 (2022) 4865–4877.

DOI: 10.1007/s12633-021-01259-1

[19] M.K Bind, S.V Singh, K.Kumar Nigam, Design and Investigation of the DM- PC-TFET-Based Biosensor for Breast Cancer Cell Detection, Trans. Electr. Electron. Mater., 24 (2023) 381–395.

DOI: 10.1007/s42341-023-00453-9

[20] R.Abdulnassir A.Singh, D.Tekilu, Assessment of Hetero-Structure Junction-Less Tunnel FET's Efficacy for Biosensing Applications, Sens Imaging, 25 (2024) 6.

DOI: 10.1007/s11220-023-00455-0

[21] Tran Thanh Hoai, Phan Thi Yen, Tran Thi Bich Dao, Luu Hai Long, Duong Xuan Anh, Luu Hai Minh, Bui Quoc Anh, Nghiem Thi Thuong, Evaluation of the cytotoxic effect of rutin prenanoemulsion in lung and colon cancer cell lines, J. Nanomater., 8867669 (2020) 1–11.

DOI: 10.1155/2020/8867669