Compaction Behavior of Stainless Steel/Carbamide Mixtures in Porous Scaffold Fabrication via Space Holder Method

Abstract:

The medical grade 316L stainless steel has been widely used for biomedical implants, including bone tissue engineering scaffolds due to its excellent mechanical properties and biocompatibility. The space holder method offers a promising approach to producing highly porous 316L stainless steel scaffolds. However, several challenges in the implementation of this method remain unresolved, particularly the difficulties in controlling the geometrical changes of space holder particles during the compaction of stainless steel/carbamide powder mixtures, leading to inability to control pore characteristics of the scaffolds produced. In this study, the compaction behavior of stainless steel/carbamide powder mixtures was investigated to understand the interactions between metal particles and space holder particles in the preparation of porous stainless steel scaffolds. The impacts of key process parameters on the green density, such as the specific net energy applied during the process and the yield pressure derived from loading-unloading compression cycles, were analyzed with the aid of the Heckel model. The study provides useful insights into these relationships, facilitating the optimization of the compaction process to achieve desired scaffold architecture and contributing to consistent fabrication of porous 316L stainless steel scaffolds.

You might also be interested in these eBooks

Info:

Pages:

113-121

Citation:

Online since:

July 2026

Funder:

The publication of this article was funded by the Delft University of Technology 10.13039/501100001831

Export:

Share:

Citation:

* - Corresponding Author

[1] J. Fan, J. Xu, X. Wen, L. Sun, Y. Xiu, Z. Zhang, T. Liu, D. Zhang, P. Wang, D. Xing, The future of bone regeneration: Artificial intelligence in biomaterials discovery, Mater. Today Commun. 40 (2024) 109982.

DOI: 10.1016/j.mtcomm.2024.109982

Google Scholar

[2] N. Aslan, B. Aksakal, F. Findik, Fabrication of porous-Ti6Al4V alloy by using hot pressing technique and Mg space holder for hard-tissue biomedical applications, J. Mater. Sci. Mater. Med . 32(7) (2021) 80.

DOI: 10.1007/s10856-021-06546-2

Google Scholar

[3] B. Arifvianto, M. A. Leeflang, J. Zhou, Diametral compression behavior of biomedical titanium scaffolds with open, interconnected pores prepared with the space holder method, J. Mech. Behav. Biomed. Mater. 68 (2017) 144-154.

DOI: 10.1016/j.jmbbm.2017.01.046

Google Scholar

[4] B. Arifvianto, M. A. Leeflang, J. Zhou, The compression behaviors of titanium/carbamide powder mixtures in the preparation of biomedical titanium scaffolds with the space holder method, Powder Technol. 284 (2015) 112-121.

DOI: 10.1016/j.powtec.2015.06.033

Google Scholar

[5] B.Q. Li, R.Z. Xie, X. Lu, Microstructure, mechanical property and corrosion behavior of porous Ti–Ta–Nb–Zr, Bioact. Mater. 5 (2020) 564-568.

DOI: 10.1016/j.bioactmat.2020.04.014

Google Scholar

[6] A. Rodriguez-Contreras, M. Punset, J. A. Calero, F. J. Gil, E. Ruperez, J. M. Manero, Powder metallurgy with space holder for porous titanium implants: A review, J. Mater. Sci. Technol. 76 (2021) 129-149.

DOI: 10.1016/j.jmst.2020.11.005

Google Scholar

[7] B. Arifvianto, J. Zhou, Fabrication of metallic biomedical scaffolds with the space holder method: A review, Mater. 7 (2014) 3588-3622.

DOI: 10.3390/ma7053588

Google Scholar

[8] M. Mirzaei, M. H. Paydar, Fabrication and Characterization of Core–Shell Density-Graded 316L Stainless Steel Porous Structure, J. Mater. Eng. Perform. 28 (2019) 221-230.

DOI: 10.1007/s11665-018-3797-5

Google Scholar

[9] Z. Abdullah, S. Ahmad, A. Ismail, N. Ahmed Khan, Processing of porous stainless steel by compaction method using egg shell as space holder, Key Eng. Mater. 791 (2018) 123-128.

DOI: 10.4028/www.scientific.net/kem.791.123

Google Scholar

[10] H. Jain, D. P. Mondal, G. Gupta, R. Kumar, S. Singh, Synthesis and characterization of 316L stainless steel foam made through two different removal process of space holder method, Manuf. Lett. 26 (2020) 33-36.

DOI: 10.1016/j.mfglet.2020.09.005

Google Scholar

[11] H. I. Bakan, A novel water leaching and sintering process for manufacturing highly porous stainless steel, Scr. Mater. 55 (2006) 203-206.

DOI: 10.1016/j.scriptamat.2006.03.039

Google Scholar

[12] H. Jain, G. Gupta, R. Kumar, D. P. Mondal, Microstructure and compressive deformation behavior of SS foam made through evaporation of urea as space holder, Mater. Chem. Phys. 223 (2019) 737-744.

DOI: 10.1016/j.matchemphys.2018.11.040

Google Scholar

[13] R. W. Heckel, Density-Pressure Relationships in Powder Compaction, Trans. Metall. Soc. AIME. 221 (1961) 671-675.

Google Scholar

[14] S. T. Hong, Y. Hovanski, C. A. Lavender, K. S. Weil, Investigation of die stress profiles during powder compaction using instrumented die, J. Mater. Eng. Perform. 17(3) (2008) 382-386.

DOI: 10.1007/s11665-008-9229-1

Google Scholar

[15] R. F. Mallender, C. J. Dangerfield, D. S. Coleman, Friction coefficients between iron powder compacts and die wall during ejection using various admixed zinc stearate lubricants, Powder Metall. 15 (1972) 130-152.

DOI: 10.1179/pom.1972.15.30.003

Google Scholar

[16] J.M. Sonnergaard, A critical evaluation of the Heckel equation, Int. J. Pharm. 193(1999)63-71.

Google Scholar

[17] ASTM Internasional, Standard Specification for Stainless Steel Bars and Shapes, ASTM A276-06. 2006.

Google Scholar