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Impact of Synthesis Temperature on the Drug Loading Capacity of Linde Type A Zeolite

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Abstract:

Linde Type A (LTA) zeolite, with its unique structural properties, has emerged as a potential candidate for controlled drug delivery in biomedical applications. This locally obtained zeolite can be utilised to deliver drugs for the treatment of cancer. The study investigated the synthesis and characterization of LTA zeolite at different temperatures (60°C, 80°C, and 105°C) and their potential for drug delivery. Fourier-transformed infrared spectroscopy (FTIR) confirmed the presence of LTA zeolite, while helium ion microscopy (HIM) and scanning electron microscopy (SEM) revealed distinct morphological changes upon drug loading. Brunauer-Emmett-Teller (BET) analysis demonstrated variations in surface area, pore size, and pore volume between raw zeolite and drug-loaded zeolite. X-ray diffraction (XRD) analysis revealed temperature-dependent changes in crystallite size and crystallinity, with average values of 40.89 nm (65.99% crystallinity) at 60°C, 28.40 nm (71.39%) at 80°C, and 29.76 nm (76.37%) at 105°C for raw zeolite. Drug loading further reduced crystallite size to 24.89 nm (70.79%), 16.44 nm (83.78%), and 26.91 nm (68.82%) at 60°C, 80°C, and 105°C, respectively. These results highlight the potential of LTA zeolite as carriers for cancer drugs, with synthesis temperature and drug loading influencing their physicochemical properties and drug delivery potential.

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Journal of Biomimetics, Biomaterials and Biomedical Engineering Vol. 73 View Preview

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Periodical:

Journal of Biomimetics, Biomaterials and Biomedical Engineering (Volume 73)

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97-111

DOI:

https://doi.org/10.4028/p-S7Thip

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Online since:

July 2026

Authors:

Savanna Nyarko*, Moses Jojo Eghan, Catharina De Lange Davies, Mercy Afadzi Tetteh, Jerry Opoku-Ansah, Raphaell Moreira, E. Johan Foster, Solomon Kingsley Katu, Elvis K. Tiburu

Keywords:

Doxorubicin, Drug Loading, Pore-Size, Specific Surface Area, Targeted, Zeolite

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© 2026 Trans Tech Publications Ltd. All Rights Reserved

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