Mn Blended Hydroxyapatite Nanoceramic: Bioactivity, Dielectric and Luminescence Studies

Abstract:

Abstract: In this study, in-vitro bioactivity of manganese blended hydroxyapatite (Mn-HAp) pellets is carried out using simulated body fluid (SBF) solution. The incubated Mn-HAp samples are characterized by XRD, FTIR and SEM/EDAX. Dielectric and photoluminescence properties of Mn-HAp samples are studied as a function of incubation period in SBF. XRD profiles show that hexagonal apatite structure remains intact after partial replacement of calcium ions by manganese ions and even after incubation. The change in absorption due to phosphate group, depicted in FTIR spectra, for incubated samples confirms growth of apatite on Mn-HAp surface. SEM/ EDAX studies suggest that Mn-HAp surface promotes the growth of apatite without changing its structure due to apatite nucleation and growth on the surface of Mn-HAp. The value of dielectric constant of Mn-HAp increases after incubation. Increase in period of immersion in m-SBF leads to decrease in dielectric constant of manganese exchanged hydroxyapatite. The photoluminescence (PL) study reveals that the Mn-HAp can be used stable and efficient blue luminescent material.

• Periodical: Journal of Biomimetics, Biomaterials and Tissue Engineering (Volume 18)
• Pages: 43-59
• DOI: https://doi.org/10.4028/www.scientific.net/JBBTE.18.43
• Online since: December 2013
• Authors: Megha Mahabole, Manjushree Bahir, Rajendra Khairnar
• Keywords: Dielectric Property, Hydroxyapatite (HA), In Vitro Bioactivity, Photoluminescence (PL)

References

[1] M.P. Ferraz, F.J. Monteiro, C.M. Manue, Hydroxyapatite nanoparticles: A review of preparation methodologies, J. of Appl. Biomater. Biomech. 2 (2004) 74-80.

[2] E. Rivera-Munoz, W. Brostow, R. Rodriguez, V.M. Castano, Growth of hydroxyapatite on silica gels in the presence of organic additives: kinetics and mechanism, Mater. Res. Innov. 4 (2001) 222-230.

DOI: 10.1007/s100190000100

[3] R.W.N. Nilen, P.W. Richter, The thermal stability of hydroxyapatite in biphasic calcium phosphate ceramic, J. of Mater. Sci.: Mater. Medic. 19(2008)1693-702.

DOI: 10.1007/s10856-007-3252-x

[4] A.E. Porter, N. Patel, J.N. Skepper, S.M. Best, W. Bonfield, Comparison of in vivo dissolution processes in hydroxyapatite and silicon-substituted hydroxyapatite bioceramics, Biomater. 24 (2003) 4609–4620.

DOI: 10.1016/s0142-9612(03)00355-7

[5] Y. Cai, S. Zhang, X. Zeng, Y. Wang, M. Qian, W. Weng, Improvement of bioactivity with magnesium and fluorine ions incorporated hydroxyapatite coatings via sol–gel deposition on Ti6Al4V alloys, Thin Solid Films. 25915 (2009) 1-5.

DOI: 10.1016/j.tsf.2009.03.071

[6] C.V. Ragel, M.Vallet-Regi, L.M. Rodriguez-Lorenzo, Preparation and in vitro bioactivity of hydroxyapatite/solgel glass biphasic material, Biomater. 23 (2002) 1865–1872.

DOI: 10.1016/s0142-9612(01)00313-1

[7] N. Pramanik, D. Mishra, I. Banerjee, T.K. Maiti, P. Bhargava, P.Pramanik, Chemical Synthesis, Characterization, and Biocompatibility Study of Hydroxyapatite/Chitosan Phosphate Nanocomposite for Bone, Tissue Engg. Appl. 200 (2009) 1-8.

DOI: 10.1155/2009/512417

[8] E.T. Baran, K.Tuzlakoglu, A.J. Salgado, R.L. Reis, Multichannel mould processing of 3D structures from microporous coralline hydroxyapatite granules and chitosan support materials for guided tissue regeneration/ engineering, J. of Mater. Science: Mater. Medici. 15 (2004) 161-165.

DOI: 10.1023/b:jmsm.0000011818.85273.cd

[9] N. Eliaz, T.M. Sridhar, U.K. Mudali, B.Raj, Electrochemical and electrophoretic deposition of hydroxyapatite for orthopaedic applications, Surf. Engg. 21 (2005) 1-5.

DOI: 10.1179/174329405x50091

[10] G.X. Ni, K.Y. Chiu, W.W. Lu, Y. Wang, Y.G. Zhang, L.B. Hao, Z.Y. Li, W.M. Lam, S.B. Lu, K.D.K. Luk, Strontium-containing hydroxyapatite bioactive bone cement in revision hip arthroplasty, Biomater. 27 (2006) 4348-4355.

DOI: 10.1016/j.biomaterials.2006.03.048

[11] L. Medvecky, R. Stulajterova, L. Parilak, J. Trpcevska, J. Durisin, S.M. Barinov, Influence of manganese on stability and particle growth of hydroxyapatite in simulated body fluid, Coll. and Surf. A: Physico chem. Engg. Aspects. 281 (2006) 221–229.

DOI: 10.1016/j.colsurfa.2006.02.042

[12] N. Rameshbabu, T.S. Sampath Kumar, T.G. Prabhakar, V.S. Sastry, K.V.G.K. Murty, K.P. Rao, Antibacterial nanosized silver substituted hydroxyapatite: Synthesis and characterization, J. of Biomed. Mater. Res. Part A. 80 (2007) 581–591.

DOI: 10.1002/jbm.a.30958

[13] G. Frost, C.W. Asling, M.M. Nelson, Skeletal deformities in manganese-deficient rats, The Anatom. Record. 134 (1959) 37–53.

DOI: 10.1002/ar.1091340105

[14] R.M. Leach Jr, A.M. Muenster, Studies on the role of manganese in bone formation: effect upon the mucopolysaccharide content of chick bone, J. of Nutrition. 78 (1962) 51-56.

DOI: 10.1093/jn/78.1.51

[15] C.R. Bowen, J.P. Gittings, I.G. Turner, F.Baxter, J.B. Chaudhuri, Dielectric and piezoelectric properties of hydroxyapatite-BaTiO3 composites, Appl. Physics Lett. 89 (2006) 1329061-63.

DOI: 10.1063/1.2355458

[16] C.C. Silva, A. Almeid, R.S. De Oliveira, A.G. Pinheiro, J.C. Goes, A.S.B. Sombra, Dielectric permittivity and loss of hydroxyapatite screen-printed thick films, J. of Mater. Sci. 38 (2003) 3713-3720.

[17] S. Hontsu, T. Matsumoto, J. Ishii, M. Nakamori, H. Tabata , T. Kawai, Electrical properties of hydroxyapatite thin films grown by pulsed laser deposition, Thin Solid Films. 295 (1997) 214–217.

DOI: 10.1016/s0040-6090(96)09146-8

[18] S.L. Shi, W. Pan, R.B. Han, C.L. Wan, Electrical and dielectric behaviours of Ti3SiC2/hydroxyapatite composites, Appl. Physics Lett. 88 (2006) 052903-052903-2

[19] P.N. Chavan, M.M. Bahir, R.U. Mene, M.P. Mahabole, R.S. Khairnar, Study of nanobiomaterial hydroxyapatite in simulated body fluid:Formation and growth of apatite, Mater. Sci. and Engg. B. 168 (2009) 224-230.

DOI: 10.1016/j.mseb.2009.11.012

[20] M.P. Mahabole, M.M .Bahir, N.V. Kalyankar, R.S. Khairnar,Effect of incubation in simulated body fluid on dielectric and photoluminescence properties of nano-hydroxyapatite ceramic doped with strontium ions, J. of Biomed. Sci.and Engg. 5 (2012) 396-405.

DOI: 10.4236/jbise.2012.57050

[21] O.A. Graeve, K. Raghunath, A. Madadi, C.W. Brandon, K.C. Glass, Luminescence variations in hydroxyapatites doped with Eu2+ and Eu3+ ions, Biomater. 31 (2010) 4259-4267.

DOI: 10.1016/j.biomaterials.2010.02.009

[22] M. Oht, M. Yasud, Y. Sugiyam, Y. Suzuki, H. Okamur, The Behavior of Rare Earth Ions in Hydroxyapatite, Crystal. ECS Trans. 16 (2009) 141-144.

[23] F.A. Muller, L. Muller, C. Zollfrank, P. Greil, Inherent luminescence of annealed biomimetic apatites, Engg. Mater. 311 (2006) 655-658.

DOI: 10.4028/www.scientific.net/kem.309-311.655

[24] R.J. Chung, T.S. Chin, H.Y. Cheng, H.W. Wen, M.F. Hsieh, Photo-luminescent hydroxyapatite coating through a bio-mimetic process, Biomol. Engg. 24 (2007) 459-461.

DOI: 10.1016/j.bioeng.2007.07.006

[25] T.Ikoma, M. Tagaya, T. Tonegawa, M. Okuda, N. Hanagata, T. Yoshioka, D. Chakarov, B. Kasemo, J. Tanaka, The Surface Property of Hydroxyapatite: Sensing with Quartz Crystal Microbalance, Key Engg. Mater. 396 – 398 (2008) 89-92.

DOI: 10.4028/www.scientific.net/kem.396-398.89

[26] A.C. Tas, Synthesis of biomimetic Ca-hydroxyapatite powders at 37°C in synthetic body fluids, Biomater. 21 (2000) 1429-1438.

DOI: 10.1016/s0142-9612(00)00019-3

[27] K. Hyun-Min, H. Teruyuki, T. Kokubo, N. Takashi, Process and kinetics of bonelike apatite formation on sintered hydroxyapatite in a simulated body fluid, Biomater. 26 (2005) 4366-4373.

DOI: 10.1016/j.biomaterials.2004.11.022