Characterization of the Morphological State of a Culture of Filamentous Microorganisms Using Digital Image Analysis

Abstract:

The paper examines the potential of the application of digital image analysis for the monitoring of morphological changes in cultures of filamentous microorganisms used in pharmaceutical production processes. First, an overview of selected methods and techniques used in digital image analysis is given with respect to their possible application in this project. This section also includes the description of corresponding software tools used in the presented study. The potential of the proposed approach is then demonstrated using a set of microscopic images from two typical productive cultivations. Finally, the obtained results are discussed within the context of a potential future application of these techniques for advanced monitoring of the given productive bioprocess.

• Periodical: International Journal of Engineering Research in Africa (Volume 18)
• Pages: 192-198
• DOI: https://doi.org/10.4028/www.scientific.net/JERA.18.192
• Online since: October 2015
• Authors: Ema Hrbková, Ludvik Hasal, Jan Nahlik, Jan Mareš, Pavel Hrnčiřík
• Keywords: Cell Morphology, Image Processing, Industrial Bioprocesses, Process Monitoring

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