In-House Synthesis and Characterization of Vitamin C and Glycerine Based Natural Deep Eutectic Solvent

Abstract:

This study introduces an innovative Natural Deep Eutectic Solvent (NADES) based on Vitamic C (L-Ascorbic acid) and glycerine, delving into its synthesis, thermophysical characterization, and potential applications. A comprehensive exploration of thermophysical properties, including density, pH, surface tension, refractive index, and viscosity, was conducted. Fourier Transform Infrared (FTIR) analysis was employed to gain insights into the molecular composition, revealing the emergence of new bonds within the NADES structure. Thermogravimetric Analysis (TGA) indicated notable weight loss post-180°C, primarily attributed to glycerin degradation. The nonlinear reduction in surface tension, refractive index, and viscosity with temperature underscores the adaptability of Ascorbic acid-based NADES for diverse industrial applications. Potential areas of utilization include pharmaceuticals as a solvent for enhancing drug solubility and stability, biotechnology in enzyme stabilization and biocatalysis, cosmetics as an antioxidant in skincare formulations, the food industry as a natural preservative and antioxidant, and environmental remediation for the extraction of heavy metals and organic pollutants. The environmentally friendly and low-toxicity characteristics of NADES position them as promising and sustainable alternatives. Nevertheless, further research and development are crucial to fine-tune their performance and customize properties to meet specific industrial requirements.

• Periodical: Key Engineering Materials (Volume 1003)
• Pages: 159-173
• DOI: https://doi.org/10.4028/p-0dwodV
• Online since: December 2024
• Authors: Muhammad Hammad Rasool*, Maqsood Ahmad, Numair Ahmed Siddiqui, Husnain Ali, Nimra Tariq Bajwa
• Keywords: Ascorbic Acid, DES, Ionic Liquids, NADES, Natural Materials, Vitamin C

References

[1] A. J. Greer, J. Jacquemin, and C. Hardacre, Industrial applications of ionic liquids, Molecules, 25 (2020) 5207.

DOI: 10.3390/molecules25215207

[2] S. K. Singh and A. W. Savoy, Ionic liquids synthesis and applications: An overview, Journal of Molecular Liquids, 297 (2020) 112038.

DOI: 10.1016/j.molliq.2019.112038

[3] T. El Achkar, H. Greige-Gerges, and S. Fourmentin, Basics and properties of deep eutectic solvents: a review, Environmental chemistry letters, 19 (2021) 3397-3408.

DOI: 10.1007/s10311-021-01225-8

[4] B. B. Hansen et al., Deep eutectic solvents: A review of fundamentals and applications, Chemical reviews, 121 (2020) 1232-1285.

[5] J. Cai, J. Xue, Y. Li, L. Wei, N. Lin, and X. Zha, Research progress on high-value-added application of lignocellulosic biomass based on deep eutectic solvent pretreatment, Biomass Conversion and Biorefinery, 12 (2023) 1-16.

DOI: 10.1007/s13399-023-04972-6

[6] A. Mannu, M. Blangetti, S. Baldino, and C. Prandi, Promising technological and industrial applications of deep eutectic systems, Materials, 14 (2021) 2494 .

DOI: 10.3390/ma14102494

[7] A. Mišan et al., The perspectives of natural deep eutectic solvents in agri-food sector, Critical reviews in food science and nutrition, 60 (2020) 2564-2592.

DOI: 10.1080/10408398.2019.1650717

[8] M. H. Rasool and M. Ahmad, Synthesis and physico-chemical characterization of novel Epsom salt based natural deep eutectic solvent, Chemical Data Collections, 44 (2023) 101004.

DOI: 10.1016/j.cdc.2023.101004

[9] M. Rasool, M. Ahmad, and S. Hashmi, A novel potassium chloride based natural deep eutectic solvent: in-house synthesis and characterization, Moroccan Journal of Chemistry, 11 (2023) 871-883.

[10] M. H. Rasool, M. Ahmad, M. Ayoub, A. Zamir, and M. A. Abbas, A review of the usage of deep eutectic solvents as shale inhibitors in drilling mud, Journal of Molecular Liquids, 361 (2022) 119673.

DOI: 10.1016/j.molliq.2022.119673

[11] J. C. Deutsch, Ascorbic acid and dehydroascorbic acid interconversion without net oxidation or reduction, Analytical biochemistry, 247 (1997) 58-62.

DOI: 10.1006/abio.1997.2035

[12] J. Pantwalawalkar, H. More, D. Bhange, U. Patil, and N. Jadhav, Novel curcumin ascorbic acid cocrystal for improved solubility, Journal of Drug Delivery Science and Technology, 61 (2021) 102233.

DOI: 10.1016/j.jddst.2020.102233

[13] N. P. E. Hikmawanti, D. Ramadon, I. Jantan, and A. Mun'im, Natural deep eutectic solvents (NADES): Phytochemical extraction performance enhancer for pharmaceutical and nutraceutical product development, Plants, 10 (2021) 2091.

DOI: 10.3390/plants10102091

[14] A. R. Jesus, A. Paiva, and A. R. C. Duarte, Current developments and future perspectives on biotechnology applications of natural deep eutectic systems, Current Opinion in Green and Sustainable Chemistry, 39 (2023) 100731.

DOI: 10.1016/j.cogsc.2022.100731

[15] C. S. Lucea et al., Kinetic study of natural deep eutectic solvents by digital images: The importance of preparation time in sensing applications, Journal of Molecular Liquids, 386 (2023) 122514.

DOI: 10.1016/j.molliq.2023.122514

[16] X. Fang et al., Insights on the potential of natural deep eutectic solvents (NADES) to fine-tune durian seed gum for use as edible food coating, Food Hydrocolloids, 132 (2022) 107861.

DOI: 10.1016/j.foodhyd.2022.107861

[17] P. Dehury, U. Mahanta, and T. Banerjee, Comprehensive Assessment on the Use of Boron Nitride-Based Nanofluids Comprising Eutectic Mixtures of Diphenyl Ether and Menthol for Enhanced Thermal Media, ACS Sustainable Chemistry & Engineering, 8 (2020) 14595-14604.

DOI: 10.1021/acssuschemeng.0c05648

[18] Z. Yang, Natural deep eutectic solvents and their applications in biotechnology, Application of ionic liquids in biotechnology, 45 (2019) 31-59.

DOI: 10.1007/10_2018_67

[19] J. Boiteux et al., NADES blend for bioactive coating design as a sustainable strategy for postharvest control, Food Chemistry, 406 (2023) 135054.

DOI: 10.1016/j.foodchem.2022.135054

[20] V. Gupta, R. Thakur, and A. B. Das, Effect of natural deep eutectic solvents on thermal stability, syneresis, and viscoelastic properties of high amylose starch, International Journal of Biological Macromolecules, 187 (2021) 575-583.

DOI: 10.1016/j.ijbiomac.2021.07.099

[21] S. N. Rashid et al., A kinetic study of ex-situ soil remediation by nickel extraction using natural deep eutectic solvent, Environmental Technology, 33 (2023) 1-14.

DOI: 10.1080/09593330.2023.2283093

[22] N. M. Morgana, E. Magdalena, M. de los Angeles Fernandez, and S. M. Fernanda, NADES for food industry innovation: Novel bioadditives based on olive oil byproducts, Food and Bioproducts Processing, 134 (2022) 193-201.

DOI: 10.1016/j.fbp.2022.05.007

[23] F. J. V. Gomez, M. Espino, M. de los Angeles Fernandez, J. Raba, and M. F. Silva, Enhanced electrochemical detection of quercetin by natural deep eutectic solvents, Analytica Chimica Acta, 936 (2016) 91-96.

DOI: 10.1016/j.aca.2016.07.022

[24] C. Cecone et al., Sustainable synthesis of cyclodextrin-based polymers by exploiting natural deep eutectic solvents, Green chemistry, 22 (2020) 5806-5814.

DOI: 10.1039/d0gc02247k

[25] M. H. Rasool, M. Ahmad, N. A. Siddiqui, and A. Z. Junejo, Eco-friendly drilling fluid: calcium chloride-based natural deep eutectic solvent (NADES) as an all-rounder additive, Energies, 16 (2023) 5533.

DOI: 10.3390/en16145533