Porous Titanium for Biomedical Applications Produced Using Coarse Titanium Powder via the Space Holder Technique

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Due to its low density, high strength to weight ratio, and been unreactive to the human body, titanium is commonly used in human bone implants. Titanium in bone implants can be used in its porous form because the porosity reduces the elastic modulus of the implant, near to that of human cortical or trabecular bone, which prevents the effects of stress-shielding. To date, majority of the published studies using the space holder (SH) method to produce porous titanium, utilized-45 μm titanium hydride dehydride (Ti-HDH) powder, or similar titanium powder. However, there is limited research conducted on the use of coarse titanium powder particles, such as-150 μm Ti-HDH powder to produce porous titanium. Fine Ti-HDH powders are known to have higher oxygen content than coarse Ti-HDH powders, thus the specimens produced from fine powders are harder, require higher compaction pressures and are expected to have lower impact resistance. The following study thus investigated the use of-150 μm Ti-HDH powder to produce porous titanium specimens, by the SH method. The porous specimens of 45 mm diameter were produced by uniaxially compacting mixtures of sodium chloride (NaCl) powder and Ti-HDH powder at 500 MPa. The NaCl powder utilized was hand sieved to a range of-500 μm. The specimens were sintered at 1150 for 4 hours in a high-vacuum tube furnace. Three porosity levels were investigated i.e. 40%, 50% and 60%. The sintered compacts were assessed for density, porosity and elastic moduli. It was found that the sintered porosity of the specimens ranged from 42.7-59.1%, and the sintered density ranged from 1.84-2.58 g/cm3. The elastic moduli of the specimens were found to reduce as the porosity increased, and ranged from 0.59-1.3 GPa, which is similar to the elastic moduli of human trabecular bone. The use of-150 μm Ti-HDH powder is thus potentially a lower cost alternative, than the use of-45 μm Ti-HDH powder, to produce porous titanium for human bone implants.

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March 2025

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[1] R.R. Boyer, Attributes, Characteristics, and Applications of Titanium and its Alloys The Journal of the Minerals, Metals and Materials Society. 62 (2010) 21-24.

Google Scholar

[2] H. Kudo, K. Iwano, and J. Nishino, Cementless or Hybrid Total Elbow Arthroplasty with Titanium-alloy Implants : A Study of Interim Clinical Results and Specific Complications,The Journal of Arthroplasty. 9 no. 3, (1994) 269-278.

DOI: 10.1016/0883-5403(94)90081-7

Google Scholar

[3] W. Wang and C. K. Poh, Titanium Alloys in Orthopaedics,in: J. Sieniawski and W. Ziaja (Eds.), Titanium Alloys - Advances in Properties Control, IntechOpen, 2013, pp.1-19.

DOI: 10.5772/56197

Google Scholar

[4] A. Illarionov, S. Belikov, S. Grib, and A. Yurovskikh, Metallic Materials for Medical Use, in XIII International Scientific -Technical Conference "Dynamic of Technical Systems", 2017, vol. 132, no. MATEC Web Conf.

DOI: 10.1051/matecconf/201713203003

Google Scholar

[5] K. T. Kim, M. Y. Eo, T. T. H. Nguyen, and S. M. Kim, General Review of Titanium Toxicity,International Journal of Implant Dentistry. 5 (2019) 1-12.

DOI: 10.1186/s40729-019-0162-x

Google Scholar

[6] R. M. Diaz-Sanchez, A. Paz-Carrion, M. A. Serrera-Figallo, D. Torres-Lagares, A. Barranco, J. R. Leon-Ramos, and J. L. Gutierrez-Perez, In Vitro and In Vivo Study of Titanium Grade IV and Titanium Grade V Implants with Different Surface Treatments,MDPI Metals 10 (2020) 1-14, doi:.

DOI: 10.3390/met10040449

Google Scholar

[7] M. H. Wu, M. H. Lee, C. Wu, P. I. Tsai, W. B. Hsu, S. I. Huang, T. H. Lin, K. Y. Yang, C. Y. Chen, S. H. Chen, C. Y. Lee, T. J. Huang, F. H. Tsau, and Y. Y. Li, In Vitro and In Vivo Comparison of Bone Growth Characteristics in Additive-Manufactured Porous Titanium, Nonporous Titanium, and Porous Tantalum Interbody Cages MDPI Materials. 15 (2022) 1-20.

DOI: 10.3390/ma15103670

Google Scholar

[8] A. Nouri, P.D. Hodgson, and C. Wen, Biomimetic Porous Titanium Scaffolds for Orthopedic and Dental Applications,in: A. Mukherjee Ed., Biomimetics Learning from Nature, IntechOpen, 2010, pp.415-450.

DOI: 10.5772/8787

Google Scholar

[9] Y. Li, Y. Xiao, and C. Liu, The Horizon of Materiobiology: A Perspective on Material-Guided Cell Behaviors and Tissue Engineering,Chemical Reviews. 117 no. 5, (2017) 4376-4421.

DOI: 10.1021/acs.chemrev.6b00654

Google Scholar

[10] M.L. Raffa, V.H. Nguyen, P. Hernigou, C. H. Flouzat-Lachaniette, and G. Haiat, Stress Shielding at the Bone-Implant Interface: Influence of Surface Roughness and of the Bone-Implant Contact Ratio Journal of Orthopaedic Research. 39 no. 6, (2020) 1174-1183.

DOI: 10.1002/jor.24840

Google Scholar

[11] I.-H. Oh, N. Nomura, and S. Hanada, Microstructures and Mechanical Properties of Porous Titanium Compacts Prepared by Powder Sintering,Materials Transactions. 43 no. 3, (2002) 443-446.

DOI: 10.2320/matertrans.43.443

Google Scholar

[12] C. Xiang, Y. Zhang, Z. Li, H. Zhang, Y. Huang, and H. Tang, Preparation and Compressive Behavior of Porous Titanium Prepared by Space Holder Sintering Process,Procedia Engineering. 27 (2012) 768-774.

DOI: 10.1016/j.proeng.2011.12.518

Google Scholar

[13] T. Sanchez, A. Mushref, M. Norrito, K. Yendall, Y. Liu, and P. Conway, The Effect of Pore Size and Porosity on Mechanical Properties and Biological Response of Porous Titanium Scaffolds,Materials Science and Engineering C. 77 (2017) 219-228.

DOI: 10.1016/j.msec.2017.03.249

Google Scholar

[14] Y. Torres, S. Lascano, J. Bris, J. Pavon, and J. Rodriguez, Development of Porous Titanium for Biomedical Applications: A Comparison between Loose Sintering and Space-Holder Techniques Materials Science and Engineering C. 37 (2012) 148-155.

DOI: 10.1016/j.msec.2013.11.036

Google Scholar

[15] S. Lascano, C. Arevalo, I. Montealegre-Melendez, S. Munoz, J. A. Rodriguez-Ortiz, P. Trueba, and Y. Torres, Porous Titanium for Biomedical Applications: Evaluation of the Conventional Powder Metallurgy Frontier and Space-Holder Technique MDPI Applied Sciences. 9 no. 5, (2019) 1-13.

DOI: 10.3390/app9050982

Google Scholar

[16] B. Ye and D.C. Dunand, Titanium Foams Produced by Solid-State Replication of NaCl Powders Materials Science and Engineering A. 528 (2010) 691-697.

DOI: 10.1016/j.msea.2010.09.054

Google Scholar

[17] J. Jia, A. Siddiq, and A. Kennedy, Porous Titanium Manufactured by a Novel Powder Tapping Method using Spherical Salt Bead Space Holders: Characterisation and Mechanical Properties,Journal of the Mechanical Behavior of Biomedical Materials. 48 (2015) 229-240.

DOI: 10.1016/j.jmbbm.2015.04.018

Google Scholar

[18] J.P. Zheng, L. J. Chen, D. Y. Chen, C. S. Shao, M. F. Yi, and B. Zhang, Effects of Pore Size and Porosity of Surface-Modified Porous Titanium Implants on Bone Tissue Ingrowth Transactions of the Nonferrous Metals Society of China. 29 no. 12, (2019) 2534-2545.

DOI: 10.1016/s1003-6326(19)65161-7

Google Scholar

[19] Y. Chen, J. E. Frith, A. Dehghan-Manshadi, D. Kent, M. Bermingham, and M. Dargusch, Biocompatible Porous Titanium Scaffolds Produced using a Novel Space Holder Technique,Journal of Biomedical Materials Research 106 no. 8, (2017) 2796-2806.

DOI: 10.1002/jbm.b.34060

Google Scholar

[20] A. Civantos, M. Giner, P. Trueba, S. Lascano, M. J. M. Garcia, C. Arevalo, M. A. Vazquez, J. P. Allain, and Y. Torres, In Vitro Bone Cell Behavior on Porous Titanium Samples: Influence of Porosity by Loose Sintering and Space Holder Techniques,MDPI Metals. 10 no. 5, (2020) 1-20.

DOI: 10.3390/met10050696

Google Scholar

[21] B. Dabrowski, W. Swieszkowski, D. Godlinski, and K. Kurzydlowski, Highly Porous Titanium Scaffolds for Orthopaedic Applications Journal of Biomedical Materials Research. 95B no. 1, (2010) 53-61.

DOI: 10.1002/jbm.b.31682

Google Scholar

[22] I.M. Robertson and G.B. Schaffer, Some Effects of Particle Size on the Sintering of Titanium and a Master Sintering Curve Model,Metallurgical and Materials Transactions A. 40 (2009) 1968-1979.

DOI: 10.1007/s11661-009-9894-1

Google Scholar

[23] D. P. Barbis, R. M. Gasior, and G. P. Walker, Titanium Powders from the Hydride-Dehydride Process,in: M. Qian and F. H. Froes (Eds.), Titanium Powder Metallurgy: Science, Technology and Applications Butterworth-Heinemann, 2015, ch. 7, pp.101-116.

DOI: 10.1016/b978-0-12-800054-0.00007-1

Google Scholar

[24] Standard Specification for Titanium and Titanium Alloy Strip, Sheet, Plate, ASTM-B265-08, A. International, Pennsylvania, USA, 2008.

Google Scholar

[25] H. Conrad, Effect of Interstitial Solutes on the Strength and Ductility of Titanium,Progress in Materials Science. 26 no. 2, (1981) 123-403.

DOI: 10.1016/0079-6425(81)90001-3

Google Scholar

[26] S. Dong, B. Wang, Y. Song, G. Ma, H. Xu, D. Savvakin, and O. Ivasishin, Comparative Study on Cold Compaction Behavior of TiH2 Powder and HDH-Ti Powder,Hindawi: Advances in Materials Science and Engineering. 2021 (2021) 1-15.

DOI: 10.1155/2021/9999541

Google Scholar

[27] S.J. Gerdemann and P. D. Jablonski, Compaction of Titanium Powders,Metallurgical and Materials Transactions A. 42A (2010) 1325-1333.

DOI: 10.1007/s11661-010-0520-z

Google Scholar

[28] P.G. Esteban, E. Baril, Y. Thomas, and E. Ruiz-Navas, Study of Compaction and Ejection of Hydrided-Dehydrided Titanium Powder Metals and Materials International 17 (2011) 45-55.

DOI: 10.1007/s12540-011-0207-z

Google Scholar

[29] Standard Test Methods for Density of Compacted or Sintered Powder Metallurgy (PM) Products Using Archimedes' Principle, B962-23, A. International, USA, 2023.

DOI: 10.1520/b0962-14

Google Scholar

[30] R.M. German, Measurement Tools and Experimental Observations,in, Sintering: From Empirical Observations to Scientific Principles. USA, Butterworth-Heinemann, 2014.

DOI: 10.1016/b978-0-12-401682-8.00004-5

Google Scholar

[31] Standard Test Methods of Compression Testing of Metallic Materials at Room Temperature E9-89a, A. International, USA, 2000.

Google Scholar

[32] R. German, Geometric Trajectories During Sintering,in: 1st ed., Sintering : From Empirical Observations to Scientific Principles. MA, USA, Butterworth-Heinemann : Elsevier, 2014, pp.141-179.

DOI: 10.1016/b978-0-12-401682-8.00006-9

Google Scholar

[33] A. Rodriguez-Contreras, M. Punset, J. A. Calero, F. J. Gil, E. Ruperez, and J. M. Manero, Powder Metallurgy with Space Holder for Porous Titanium Implants: A Review,Journal of Materials Science & Technology. 76 (2021) 129-149.

DOI: 10.1016/j.jmst.2020.11.005

Google Scholar

[34] C. Ohman-Magi, O. Holub, D. Wu, R. M. Hall, and C. Persson, Density and Mechanical Properties of Vertebral Trabecular Bone-A Review,JOR Spine. 4 (2021) 1-15.

DOI: 10.1002/jsp2.1176

Google Scholar

[35] E. Lakatos, L. Magyar, and I. Bojtar, Material Properties of the Mandibular Trabecular Bone,Hindawi: Journal of Medical Engineering. 2014 (2014) 1-8.

DOI: 10.1155/2014/470539

Google Scholar

[36] M. Steytler, The Commercial Viability of Direct Powder Rolled Titanium: A Systematic Review and Market Analysis Masters Degree, Centre for Materials Engineering, University of Cape Town, 2018.

DOI: 10.3390/ma13092124

Google Scholar