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HomeKey Engineering MaterialsKey Engineering Materials Vol. 1027Bleached Shellac/Fatty Substance In Situ Matrix...

Bleached Shellac/Fatty Substance In Situ Matrix for Localized Metronidazole Delivery

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Abstract:

The periodontitis leads to the formation of periodontal pockets, which provide an ideal site for localized antimicrobial drug delivery for therapy. In this study, metronidazole (Met)-loaded in-situ matrix (ISM) systems were developed to assess their physical and drug release characteristics. Bleached shellac (BS) and fatty compounds such as beeswax, carnauba wax, candelilla wax, shellac wax, and stearic acid (SA) were tested as matrix-forming agents. ISM systems containing BS and SA in BS ratios of 2:1, 1:1, and 1:2 at 30% w/w were chosen because they resulted in clear, liquid-like ISMs. Increasing the BS content raised both the density and viscosity of the ISM. Upon injection into simulated crevicular fluid these liquid ISMs quickly formed solid matrices. Drug release was notably prolonged, with only around 6% released within the first day and sustained over six days. Met-loaded BS-SA ISM shows promise as a delivery system for intra-periodontal pocket route. However, further studies should focus on modulating release profile to improve drug delivery.

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Periodical:

Key Engineering Materials (Volume 1027)

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3-8

DOI:

https://doi.org/10.4028/p-P0M2y6

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Online since:

October 2025

Authors:

Thawatchai Phaechamud, Sarun Tuntarawongsa, Napaphol Puyathorn*

Keywords:

Bleached Shellac, In Situ Matrix, Stearic Acid

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© 2025 Trans Tech Publications Ltd. All Rights Reserved

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