Citric Acid-Derived Disulphide Polymers as Carriers for Dual Drug Delivery in Chemotherapy Applications

Abstract:

Disulphide-containing polymers have recently been recognized as an invaluable material in delivering chemotherapeutic drug. Disulphide-based polymers are considered potential candidates because of their sensitivity to redox conditions and their stability in the challenging environment of the upper GI tract. In this study, three polymers have been successfully synthesised via oxidation of citric acid derivative-thiolated monomer and dithiol monomers. Three disulphide-based polymers were successfully synthesized and used to encapsulate docetaxel and salinomycin, demonstrating their applicability for colon-targeted drug delivery.

• Periodical: Key Engineering Materials (Volume 1058)
• Pages: 181-187
• DOI: https://doi.org/10.4028/p-A76rM0
• Online since: June 2026
• Authors: Mat Yusuf Siti Nur Aishah*, Ong Huey Ching, Lim Vuanghao
• Keywords: Citric Acid, Disulphide, Docetaxel, Drug Delivery, Salinomycin

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