Preparation of Poly(Lactic Acid) Composite Hollow Spheres with an Open Channel

Abstract:

Novel hollow spheres for bone fillers incorporating cells were prepared using composites consisting of poly(lactic acid) and calcium carbonates. An open channel of ~800 µm in diameter was easily formed using a chemical etching method to provide a pathway to the interior of the sphere. Cells could migrate through the open channel into the interior of the sphere. Bonelike apatite coating on the surface of the sphere was prepared by soaking in calcium chloride solution to supply excess Ca2+ ions on the surface and subsequently by soaking in simulated body fluid. The hollow spheres with an open channel may be one of the great potential candidates as novel bone fillers combined with a cell-delivery system.

• Periodical: Key Engineering Materials (Volumes 284-286)
• Pages: 301-304
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.284-286.301
• Online since: April 2005
• Authors: Hirotaka Maeda, Noriko Miura, Toshihiro Kasuga, Masayuki Nogami
• Keywords: Bone Filler, Calcium Carbonate, Composite, Hollow Sphere, Poly(lactic acid) (PLA)

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