Fabrication of Porous Calcium Phosphate Bioceramics as Synthetic Cortical Bone Graft

Y.H. Hsu; I.G. Turner; A.W. Miles

doi:10.4028/www.scientific.net/KEM.284-286.305

Paper Titles

Effect of Microstructure on Osteoinductivity of Biomaterials
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Experimental Study on the Osteoinduction of Calcium Phosphate Biomaterials In Vivo and the Capability of Supporting Osteoblast Proliferation In Vitro
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Micro-Spectrometric Investigations of Inorganic Components of the Black Corals for Biomedical Applications
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Preparation of Poly(Lactic Acid) Composite Hollow Spheres with an Open Channel
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Fabrication of Porous Calcium Phosphate Bioceramics as Synthetic Cortical Bone Graft
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Method for Tailoring and Control the Morphology, Size and Porosity of Calcium Phosphate Granules
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Effect of Calcium Phosphate Glass on Compressive Strength of Macroporous Hydroxyapatite Scaffold
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Cytocompatibility Studies of a Novel Bioactive Glass Coated Porous Hydroxyapatite Bioceramic for Use as a Bone Substitute
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Morphology of Porous Hydroxyapatite Scaffold for Hard Tissue Formation
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HomeKey Engineering MaterialsKey Engineering Materials Vols. 284-286Fabrication of Porous Calcium Phosphate...

Fabrication of Porous Calcium Phosphate Bioceramics as Synthetic Cortical Bone Graft

Abstract:

The aim of this study was to fabricate porous Hydroxyapatite/Tricalcium phosphate (HA/TCP) bioceramics with an adequate degree of interconnected porosity combined with optimal mechanical properties. Porous HA/TCP bioceramics with interconnected porosity and the controlled pore sizes necessary to simulate natural bone tissue morphology were fabricated by a novel technique of vacuum impregnation of reticulated polymeric foams with ceramic slip. By varying the characteristics of the slips and using foams of different pores per inch (ppi), samples of porous HA/TCP, blocks and granules, with a wide range of pore sizes were successfully manufactured. Functionally gradient materials (FGM) with porosity gradients were also made and no weakness was found at the interface. The pore size of the HA/TCP bioceramics was in the range of 197 – 254 µm (for 20 ppi foam), 143 – 182 µm (for 30 ppi foam) and 105 – 127 µm (for 45 ppi foam). The compressive strengths and the apparent densities of the HA/TCP samples were in the range of 30 –170 MPa and 2.34 – 2.76 g/cm3 respectively. These results indicate that it is possible to manufacture open pore HA/TCP bioceramics with compressive strengths comparable to human bone which could be of clinical interest.

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Key Engineering Materials (Volumes 284-286)

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305-308

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https://doi.org/10.4028/www.scientific.net/KEM.284-286.305

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Online since:

April 2005

Authors:

Y.H. Hsu, I.G. Turner, A.W. Miles

Keywords:

Bioceramic, Calcium Phosphate, Hydroxyapatite (HAP)

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