A Study on PELGE Nanoparticles as Controlled Drug Delivery Systems for Intravenous
The objective of this study was to evaluate the in vivo characteristics of poly (ethylene glycol)-poly (lacticacid-co-glycolicacid)-poly (ethylene- glycol) (PELGE) copolymers as drug carriers. In order to test this circulation time, mitoxantrone (DHAQ) was used as a model drug in this study. DHAQ nanoparticles (DHAQ-NP) were prepared, subsequently the DHAQ-NP were evaluated by measuring the drug concentration in plasma after intravenous administration via the tail vein of mice. The circulation time of the DHAQ-NP were tested. The results showed prolonged mitoxantrone (DHAQ) residence in systemic blood circulation.
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
Y. R. Duan et al., "A Study on PELGE Nanoparticles as Controlled Drug Delivery Systems for Intravenous", Key Engineering Materials, Vols. 288-289, pp. 163-166, 2005