A Study on PELGE Nanoparticles as Controlled Drug Delivery Systems for Intravenous

You Rong Duan; W.S. Liu; J. Liu; Z.R. Zhang

doi:10.4028/www.scientific.net/KEM.288-289.163

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 288-289A Study on PELGE Nanoparticles as Controlled Drug...

A Study on PELGE Nanoparticles as Controlled Drug Delivery Systems for Intravenous

Abstract:

The objective of this study was to evaluate the in vivo characteristics of poly (ethylene glycol)-poly (lacticacid-co-glycolicacid)-poly (ethylene- glycol) (PELGE) copolymers as drug carriers. In order to test this circulation time, mitoxantrone (DHAQ) was used as a model drug in this study. DHAQ nanoparticles (DHAQ-NP) were prepared, subsequently the DHAQ-NP were evaluated by measuring the drug concentration in plasma after intravenous administration via the tail vein of mice. The circulation time of the DHAQ-NP were tested. The results showed prolonged mitoxantrone (DHAQ) residence in systemic blood circulation.

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Periodical:

Key Engineering Materials (Volumes 288-289)

Pages:

163-166

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.288-289.163

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Online since:

June 2005

Authors:

You Rong Duan, W.S. Liu, J. Liu, Z.R. Zhang

Keywords:

Intravenous, Mitoxantrone, Nanoparticle, Pelge

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