A Study on PELGE Nanoparticles as Controlled Drug Delivery Systems for Intravenous

Abstract:

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The objective of this study was to evaluate the in vivo characteristics of poly (ethylene glycol)-poly (lacticacid-co-glycolicacid)-poly (ethylene- glycol) (PELGE) copolymers as drug carriers. In order to test this circulation time, mitoxantrone (DHAQ) was used as a model drug in this study. DHAQ nanoparticles (DHAQ-NP) were prepared, subsequently the DHAQ-NP were evaluated by measuring the drug concentration in plasma after intravenous administration via the tail vein of mice. The circulation time of the DHAQ-NP were tested. The results showed prolonged mitoxantrone (DHAQ) residence in systemic blood circulation.

Info:

Periodical:

Key Engineering Materials (Volumes 288-289)

Edited by:

Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata

Pages:

163-166

DOI:

10.4028/www.scientific.net/KEM.288-289.163

Citation:

Y. R. Duan et al., "A Study on PELGE Nanoparticles as Controlled Drug Delivery Systems for Intravenous", Key Engineering Materials, Vols. 288-289, pp. 163-166, 2005

Online since:

June 2005

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Price:

$35.00

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