Chitosan Derivatives as Gene Carriers
Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this review paper, chemical modification of chitosan for enhancement of cell specificity and transfection efficiency was explained. Also, chemical modification of chitosan for the stability of chitosan/DNA complexes was reviewed.
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
T. H. Kim et al., "Chitosan Derivatives as Gene Carriers", Key Engineering Materials, Vols. 288-289, pp. 97-100, 2005