Chitosan Derivatives as Gene Carriers

Tae Hee Kim; In Kyu Park; Su Il Kim; Hwan Jeong Jeong; Hee Seung Bom; Chong Su Cho

doi:10.4028/www.scientific.net/KEM.288-289.97

Paper Titles

Tissue Engineered Bone Formation with Polymer/Ceramic Composites by Press-and-Baking Method
p.79

Poly-N-Acetyl Glucosamine-SO₄ for Repairing Osteochondral Defect in Rabbits
p.83

Study on Poly(β-Hydroxybutyrate-Co-β-Hydroxyvalerate)/Bioglass Composites as Scaffold for Tissue Engineering
p.87

Chitosan-Based Scaffolds for Hepatocyte Culture
p.91

Chitosan Derivatives as Gene Carriers
p.97

Construction of Biodegradable Multilayer Films via Layer-by-Layer Self-Assembly as Gene Delivery System
p.101

Anti-DNA Antibody/Cationic Lipid Micelles for Plasmid DNA Gene Delivery
p.105

Tumor Targeting of Plasmid DNA by Dextran Conjugation Based on Metal Coordination
p.109

Preparation of DNA Hybrid Polyethersulfone Microspheres for Endocrine Disruptor Removal
p.113

HomeKey Engineering MaterialsKey Engineering Materials Vols. 288-289Chitosan Derivatives as Gene Carriers

Chitosan Derivatives as Gene Carriers

Abstract:

Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this review paper, chemical modification of chitosan for enhancement of cell specificity and transfection efficiency was explained. Also, chemical modification of chitosan for the stability of chitosan/DNA complexes was reviewed.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Key Engineering Materials (Volumes 288-289)

Pages:

97-100

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.288-289.97

Citation:

Cite this paper

Online since:

June 2005

Authors:

Tae Hee Kim, In Kyu Park, Su Il Kim, Hwan Jeong Jeong, Hee Seung Bom, Chong Su Cho

Keywords:

Chemical Modification, Chitosan (CS), Gene Carrier, Transfection Efficiency

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] J. D. Harris, and N. R. Lemoine, Trends in Genetics Vol. 12 (1996), p.400.

Google Scholar

[2] A. Smith, Annu. Rev. Microbiol Vol. 49 (1995), p.807.

Google Scholar

[3] K.Y. Lee, I.C. Kwon, Y.H. Kim, W.H. Jo, and S.Y. Jeong, J. Control Rel. Vol. 51 (1998), p.213.

Google Scholar

[4] G. Y. Wu, and C. H. Wu. Adv Drug Deliv Rev. Vol. 29 (1998), p.243.

Google Scholar

[5] T.H. Kim, I.K. Park, J.W. Nah, Y.J. Choi, and C.S. Cho, Biomaterials. Vol. 25 (2004), p.3784.

Google Scholar

[6] I.K. Park, T.H. Kim, S.I. Kim, T. Akaike, and C.S. Cho, J. Disper. Sci. Tech. Vol. 24 (2003), p.489.

Google Scholar

[7] T.M. Allen, Trends Pharmacol. Sci. Vol. 15 (1994), p.215.

Google Scholar

[8] I. K. Park,Y. H. Park, B.A. Shin, E.S. Choi, Y.R. Kim, T. Akaike, and C.S. Cho, J. Control Rel. Vol. 69 (2000), p.97.

Google Scholar

[9] I. K. Park, T. H. Kim, Y. H. Park, B. A. Shin, E. S. Choi, E. H. Chowdhury. T. Akiake, and C. S. Cho, J. Control Rel. Vol. 76 (2001), p.349.

Google Scholar

[10] I. K. Park, J. E. Ihm, Y. H. Park, Y. J. Choi, S. I. Kim, W. J. Kim, T. Akaike, and C. S. Cho, J. Control Rel. Vol. 86 (2003), p.349.

Google Scholar

[11] J. Zabner, A.J. Fasbender, T. Moninger, K.A. Poellinger, and M.J. Welsh, J Biol. Chem. Vol. 270 (1995), p.18997.

DOI: 10.1074/jbc.270.32.18997

Google Scholar

[12] D.W. Pack, D. Putnam, and R. Langer, Biotechnol Bioeng. Vol. 67 (2000), p.217.

Google Scholar

[13] T.H. Kim J.E. Ihm Y.J. Choi, J.W. Nah, and C.S. Cho,J. Control Rel. Vol. 93 (2003).

Google Scholar

[13] .

Google Scholar