Preparation of DNA Hybrid Polyethersulfone Microspheres for Endocrine Disruptor Removal

Changsheng Zhao; Kaiguang Yang; Xian Wen; Fan Li; Xiangben Zheng; Norio Nishi

doi:10.4028/www.scientific.net/KEM.288-289.113

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Construction of Biodegradable Multilayer Films via Layer-by-Layer Self-Assembly as Gene Delivery System
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Anti-DNA Antibody/Cationic Lipid Micelles for Plasmid DNA Gene Delivery
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Tumor Targeting of Plasmid DNA by Dextran Conjugation Based on Metal Coordination
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Preparation of DNA Hybrid Polyethersulfone Microspheres for Endocrine Disruptor Removal
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Injectable Supramolecular Hydrogels Self-Assembled by Polymers and Cyclodextrins for Controlled Drug Delivery
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Controlled Release Technology Suppresses the Progression of Disseminated Pancreatic Cancer Cells
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An Implantable Immunosuppressive Cyclosporine Drug Delivery System
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Enzyme-Resistant Starch for Oral Colon-Targeting Drug Delivery System
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HomeKey Engineering MaterialsKey Engineering Materials Vols. 288-289Preparation of DNA Hybrid Polyethersulfone...

Preparation of DNA Hybrid Polyethersulfone Microspheres for Endocrine Disruptor Removal

Abstract:

In this paper, DNA hybrid polyethersulfone (PES) microspheres, including DNA-loaded porous particles and DNA-encapsulated hollow particles, are fabricated using a liquid-liquid phase separation method based on precipitation technique; the microspheres are then used for the removal of poisonous organic chemicals and endocrine disruptors. With the increase of the DNA amount incorporated into the spheres, the removal ratios increased both for the poisonous organic chemicals and endocrine disruptors. The particles without DNA also remove and accumulate poisonous organic chemicals due to the high porosity of the spheres. The results suggested that DNA hybrid PES particles could be prepared by a liquid-liquid phase separation method, and have potential to serve as a useful functional biomaterial for medical, engineering, and environmental application.