Injectable Supramolecular Hydrogels Self-Assembled by Polymers and Cyclodextrins for Controlled Drug Delivery

Abstract:

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Of many polymeric biomaterials, hydrogels are of special importance because of their favorable biocompatibility and pertinence in delivering delicate bioactive agents such as proteins. Physical hydrogels have attracted much attention for controlled drug delivery because of the mild and aqueous conditions involved in trapping bioactive agents. This paper reviews our recent progress on developing a new class of physical hydrogels based on the supramolecular self-assembly between cyclodextrins and bioabsorbable poly(ethylene oxide) (PEO) or its copolymers. Being thixotropic, the hydrogels can be injected through needles and applied as injectable drug delivery systems. The properties of the hydrogels also can be fine-tuned with triblock copolymers where PEO segments flank hydrophobic or biodegradable segments in the middle.

Info:

Periodical:

Key Engineering Materials (Volumes 288-289)

Edited by:

Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata

Pages:

117-120

DOI:

10.4028/www.scientific.net/KEM.288-289.117

Citation:

J. Li et al., "Injectable Supramolecular Hydrogels Self-Assembled by Polymers and Cyclodextrins for Controlled Drug Delivery", Key Engineering Materials, Vols. 288-289, pp. 117-120, 2005

Online since:

June 2005

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Price:

$35.00

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