Porous Composite with Tunnel-like Interconnecting Pores of Hydroxyapatite with Magnetite Particles

Abstract:

Porous composites of magnetite / hydroxyapatite with bimodal pore size distribution were prepared by hydrothermal method. Magnetite particles of about 1 µm in size with polyhedral shape were dispersed into hydroxyapatite porous matrix. The hydroxyapatite particles were rod-shaped crystals and the size of crystals were about 10 µm in length with the aspect ratio of over 25. Rod-shaped hydroxyapatite crystals were locked together to make micro-pores of about 0.8 µm in size. In addition, macro-pores of about 400 µm in size were prepared by our unique method. Hydroxyapatite in this composite was non-stoichiometric hydroxyapatite with calcium deficient composition. This composite must have the advantage of adsorptive activity and osteoconductivity, because the hydroxyapatite has many specific crystal surface and micro-pores. The composites of magnetite / hydroxyapatite must be suitable for the hyperthermia therapy of cancer in bones.

• Periodical: Key Engineering Materials (Volumes 309-311)
• Pages: 1039-1042
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.309-311.1039
• Online since: May 2006
• Authors: Koji Ioku, Setsuaki Murakami, Takashi Atsumi, Balachamdran Jeyadevan, Emile Hideki Ishida
• Keywords: Composite, Hydrothermal, Hydroxyapatite (HAP), Hyperthermia, Magnetite

References

[1] M. Jarcho: Clin. Orthop. Vol. 157 (1981), p.259.

[2] K. Ioku: J. Soc. Inorg. Mater. Japan Vol. 3 (1996), p.412.

[3] K. Ioku, M. Yoshimura, S. Somiya: Biomaterials Vol. 11 (1990), p.57.

[4] K. Ioku, M. Toda, H. Fujimori, S. Goto and M. Yoshimura: Key Engineering Materials Vol. 254-256, (2004), p.19.

DOI: 10.4028/www.scientific.net/kem.254-256.19

[5] K. Ioku, M. Fukuhara, H. Fujimori, and S. Goto: Korean J. Ceram. Vol. 5 (1999), p.115.

[6] R. K. Gilchrist et al: Annals of surgery Vol. 146 (1957), p.596.

[7] A. Okada: Handbook of Advanced Ceramics (Elsevier Academic 2003), p.407.

[8] M. Shinkai, H. Honda and T. Kobayashi: Society of Chemical Engineers. Japan, Vol. 64 (2000), p.14.

[9] Ming Ma, Ya Wu, Jie Zhou, Yongkang Sun, Yu Zhang and Ning Gu: Journal of Magnetism and Magnetic Materials Vol. 268 (2004), p.33.

[10] T. Yao and T. Kokubo: Ceramics Vol. 28, 7 (1993), p.679.

[11] H. Monma and T. Kanazawa: J. Ceram. Soc. Japan (Yogyo-Kyokai-Shi), Vol. 84 (1976), p.209.

[12] M. Yoshimura, H. Suda, K. Okamoto and K. Ioku: J. Mater. Sci. Vol. 29 (1994), p.3399.

[13] K. Ioku, H. Misumi, H. Fujimori, S. Goto and M. Yoshimura: Proc. 5th Int. Conf. Solvo-Thermal Reactions (Rutgers, The State Univ. of NJ, USA 2002), p.233 � � � � � � � � � � � �� � �� � �� � �� � �� �� �� �� HPX����� � �2 H.