Evaluation of Pore Architecture in Hydroxyapatite/Collagen Scaffold Using Micro Computed Tomography

Shunji Yunoki; Toshiyuki Ikoma; Akira Monkawa; Kazushi Ohta; Masanori Kikuchi; M. Tanaka

doi:10.4028/www.scientific.net/KEM.309-311.1091

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 309-311Evaluation of Pore Architecture in...

Evaluation of Pore Architecture in Hydroxyapatite/Collagen Scaffold Using Micro Computed Tomography

Abstract:

Hydroxyapatite/collagen (HAp/Col) composite scaffold with unidirectionally elongated pores (scaffold-U) was fabricated by the unidirectional solidification with ice growth and subsequent freeze-dry process. The pore architecture in the composite was evaluated by using scanning electron microscopy (SEM) and micro computed tomography (micro-CT) with a high resolution. The SEM observation showed that the scaffold-U had unidirectional pores elongated along the vertical direction (i.e. ice growth direction), however the horizontal cross-section showed quite different pore morphology: spindle-shaped pores with random direction. The 3-D micro-CT image of the scaffold-U simultaneously showed the microstructure of the unidirectionally elongated pore and the cross-sectional pore, indicating that the interconnected micropores were successfully fabricated along the ice growth direction. The micro-CT is a powerful tool for the visualization of 3-D pore structure.

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Periodical:

Key Engineering Materials (Volumes 309-311)

Pages:

1091-1094

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.309-311.1091

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Online since:

May 2006

Authors:

Shunji Yunoki, Toshiyuki Ikoma, Akira Monkawa, Kazushi Ohta, Masanori Kikuchi, M. Tanaka

Keywords:

Collagen, Hydroxyapatite (HAP), Interconnected Pore, Micro Computed Tomography (μ-CT), Nanocomposite, Scanning Electron Microscope (SEM)

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