High Cellular Biocompatibility of Calcium Carbonate / Poly (Lactic Acid) Composites Doped with Silicon

Abstract:

Article Preview

Silicon-doped calcium carbonate / poly (lactic acid) composites (Si-CCPC) were estimated in cellular biocompatibility with culture tests using osteoblast-like cells (MC3T3-E1) and mesenchymal stem cells (MSC). The cellular biocompatibility of Si-CCPC was enhanced by coating with bone-like hydroxycarbonate apatite (b-HA) formed by simulated body fluid immersion. The b-HA was formed on Si-CCPC after 3-days of immersion and closely bonded with Si-CCPC. Numerous MC3T3-E1 and MSC showed good adhesion on the b-HA with extending their lamellipodia. The number of adhering MC3T3-E1 on Si-CCPC coated with the b-HA was higher than that on Si-CCPC. The b-HA has excellent biocompatibility and silicon is regarded to stimulate osteoblast and bone formation in vivo and vitro. The b-HA containing silicon on Si-CCPCis expected to enhance the cellular adheresion, proliferation and differentiation.

Info:

Periodical:

Key Engineering Materials (Volumes 309-311)

Main Theme:

Edited by:

Takashi Nakamura, Kimihiro Yamashita and Masashi Neo

Pages:

1113-1116

DOI:

10.4028/www.scientific.net/KEM.309-311.1113

Citation:

A. Obata et al., "High Cellular Biocompatibility of Calcium Carbonate / Poly (Lactic Acid) Composites Doped with Silicon", Key Engineering Materials, Vols. 309-311, pp. 1113-1116, 2006

Online since:

May 2006

Export:

Price:

$35.00

In order to see related information, you need to Login.

In order to see related information, you need to Login.