High Cellular Biocompatibility of Calcium Carbonate / Poly (Lactic Acid) Composites Doped with Silicon

Akiko Obata; Hirotaka Maeda; Toshihiro Kasuga

doi:10.4028/www.scientific.net/KEM.309-311.1113

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 309-311High Cellular Biocompatibility of Calcium...

High Cellular Biocompatibility of Calcium Carbonate / Poly (Lactic Acid) Composites Doped with Silicon

Abstract:

Silicon-doped calcium carbonate / poly (lactic acid) composites (Si-CCPC) were estimated in cellular biocompatibility with culture tests using osteoblast-like cells (MC3T3-E1) and mesenchymal stem cells (MSC). The cellular biocompatibility of Si-CCPC was enhanced by coating with bone-like hydroxycarbonate apatite (b-HA) formed by simulated body fluid immersion. The b-HA was formed on Si-CCPC after 3-days of immersion and closely bonded with Si-CCPC. Numerous MC3T3-E1 and MSC showed good adhesion on the b-HA with extending their lamellipodia. The number of adhering MC3T3-E1 on Si-CCPC coated with the b-HA was higher than that on Si-CCPC. The b-HA has excellent biocompatibility and silicon is regarded to stimulate osteoblast and bone formation in vivo and vitro. The b-HA containing silicon on Si-CCPCis expected to enhance the cellular adheresion, proliferation and differentiation.

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Periodical:

Key Engineering Materials (Volumes 309-311)

Pages:

1113-1116

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.309-311.1113

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Online since:

May 2006

Authors:

Akiko Obata, Hirotaka Maeda, Toshihiro Kasuga

Keywords:

Bone-Like Apatite, Calcium Carbonate, Composite, Poly(lactic acid) (PLA), Silicon

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