Apatite Formation on Synthetic Polypeptide with β Sheet Structure in a Solution Mimicking Body Environment
Our previous study presented that sericin, a kind of silk protein, had high ability of apatite formation under a condition mimicking body environment when the sericin contains high content of β sheet structure. To confirm the effectiveness of β sheet structure on apatite nucleation, we attempted to synthesize of polypeptide containing β sheet structure and investigate apatite formation in 1.5SBF that has 1.5 times the inorganic ion concentrations of human blood plasma. Poly(FEFEFEFG) was synthesized as the polypeptide consisting mainly of β sheet structure. Formation of hydroxyapatite was observed on the film of the poly(FEFEFEFG) after soaking in 1.5SBF within 7 days. We could confirm that β sheet structure was effective even in the synthetic polypeptide.
Takashi Nakamura, Kimihiro Yamashita and Masashi Neo
A. Takeuchi et al., "Apatite Formation on Synthetic Polypeptide with β Sheet Structure in a Solution Mimicking Body Environment", Key Engineering Materials, Vols. 309-311, pp. 489-492, 2006