Apatite Formation on Synthetic Polypeptide with β Sheet Structure in a Solution Mimicking Body Environment

Abstract:

Our previous study presented that sericin, a kind of silk protein, had high ability of apatite formation under a condition mimicking body environment when the sericin contains high content of β sheet structure. To confirm the effectiveness of β sheet structure on apatite nucleation, we attempted to synthesize of polypeptide containing β sheet structure and investigate apatite formation in 1.5SBF that has 1.5 times the inorganic ion concentrations of human blood plasma. Poly(FEFEFEFG) was synthesized as the polypeptide consisting mainly of β sheet structure. Formation of hydroxyapatite was observed on the film of the poly(FEFEFEFG) after soaking in 1.5SBF within 7 days. We could confirm that β sheet structure was effective even in the synthetic polypeptide.

• Periodical: Key Engineering Materials (Volumes 309-311)
• Pages: 489-492
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.309-311.489
• Online since: May 2006
• Authors: Akari Takeuchi, Chikara Ohtsuki, Masanobu Kamitakahara, Shinichi Ogata, Masao Tanihara, Toshiki Miyazaki
• Keywords: Biomimetic Process, Hydroxyapatite (HAP), Peptide, Simulated Body Fluid (SBF), β Sheet

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