Apatite Formation on Synthetic Polypeptide with β Sheet Structure in a Solution Mimicking Body Environment

Abstract:

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Our previous study presented that sericin, a kind of silk protein, had high ability of apatite formation under a condition mimicking body environment when the sericin contains high content of β sheet structure. To confirm the effectiveness of β sheet structure on apatite nucleation, we attempted to synthesize of polypeptide containing β sheet structure and investigate apatite formation in 1.5SBF that has 1.5 times the inorganic ion concentrations of human blood plasma. Poly(FEFEFEFG) was synthesized as the polypeptide consisting mainly of β sheet structure. Formation of hydroxyapatite was observed on the film of the poly(FEFEFEFG) after soaking in 1.5SBF within 7 days. We could confirm that β sheet structure was effective even in the synthetic polypeptide.

Info:

Periodical:

Key Engineering Materials (Volumes 309-311)

Main Theme:

Edited by:

Takashi Nakamura, Kimihiro Yamashita and Masashi Neo

Pages:

489-492

DOI:

10.4028/www.scientific.net/KEM.309-311.489

Citation:

A. Takeuchi et al., "Apatite Formation on Synthetic Polypeptide with β Sheet Structure in a Solution Mimicking Body Environment", Key Engineering Materials, Vols. 309-311, pp. 489-492, 2006

Online since:

May 2006

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Price:

$35.00

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