Thin Sol-Gel Films on Fracture Fixation Material for the Controlled Release of Antibiotics

Shula Radin; Javad Parvizi; Paul Ducheyne

doi:10.4028/www.scientific.net/KEM.309-311.759

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 309-311Thin Sol-Gel Films on Fracture Fixation Material...

Thin Sol-Gel Films on Fracture Fixation Material for the Controlled Release of Antibiotics

Abstract:

Previously, the properties of room temperature processed silica sol gel (also called xerogels) as resorbable and biocompatible controlled release systems were described. It was demonstrated that drugs and macromolecules with a variety of properties and characteristics could be released in a controlled manner. In this study, we focus on the synthesis of antibacterial thin solgel films on intramedullary nails and fracture fixation materials. We determine the effect of processing parameters on the in vitro properties and demonstrated a time- and load- dependent release of vancomycin from the film. This study suggests that thin sol-gel films hold great promise for the prevention and treatment of bone infections.

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Periodical:

Key Engineering Materials (Volumes 309-311)

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759-762

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.309-311.759

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Online since:

May 2006

Authors:

Shula Radin, Javad Parvizi, Paul Ducheyne

Keywords:

Antibiotics, Controlled-Release, Sol-Gel (SG), Thin Film

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References

[1] S. Radin and P. Ducheyne: Nanostructural control of implantable xerogels for the controlled release of biomolecules " in R. Reis, S. Weiner, Learning form nature how to design new implantable biomaterials, Kluwer, The Netherlands, (2004).

DOI: 10.1007/1-4020-2648-x_4

Google Scholar

[2] H. Bottcher, P. Slowik, W. Suss: J. Sol-gel Sci Tech. Vol. 13 (1998), pp.277-81.

Google Scholar

[3] M. Ahola, P. Kortesuo, I. Kangasniemi, J. Kiesvaara, A. Yli-Urpo: Int. J. Pharm. Vol. 195 (2000), pp.219-27.

DOI: 10.1016/s0378-5173(99)00403-2

Google Scholar

[4] S.B. Nicoll, S. Radin, E. M. Santos, R.S. Tuan, P. Ducheyne: Biomaterials Vol. 18 (1997), pp.853-859.

Google Scholar

[5] E.M. Santos, S. Radin, P. Ducheyne: Biomaterials Vol. 20 (1999), pp.1695-1700.

Google Scholar

[6] S. Radin, P. Ducheyne, T. Kamplain, B.H. Tan: J. Biomed. Mater. Res. Vol. 57 (2001), pp.313-20.

Google Scholar

[7] W. Aughenbaugh, S. Radin, P. Ducheyne: J. Biomed. Mater. Res. Vol. 57 (2001), pp.321-26.

Google Scholar

[8] S. Radin, G. El-Bassyouni, E.J. Vreslovic, E. Schepers, P. Ducheyne: Biomaterials Vol. 26 (2005), pp.1043-52.

Google Scholar

[10] C.J. Brinker, G.W. Scherer: Sol-gel science. The physics and chemistry of sol-gel processing (1990) Ch. 13, pp.787-838.

DOI: 10.1016/b978-0-08-057103-4.50019-2

Google Scholar

[11] M. Gugliemi, P. Colombo, F. Peron, L. Mancinelli Degli Espoti: J. Mater. Sci. Vol. 27 (1992), p.5052.

Google Scholar