Preparation of Poly(Lactic Acid) Hybrid Membranes Containing Silica

Abstract:

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A novel poly(lactic acid) (PLA)/calcium carbonates hybrid membrane containing silica was prepared using aminopropyltriethoxysilane (APTES) for biodegradable bone guided regeneration. Carboxy groups in PLA made a chemical bond with amino groups in APTES, resulting in the formation of the hybrid membrane. The silica-hybridized PLA was an amorphous phase. The membrane formed hydroxycarbonate apatite (HCA) on its surface after 3 d of soaking in simulated body fluid (SBF). After soaking the membrane in SBF, almost no Si was present in SBF. X-ray energy dispersive spectroscopy showed the HCA layer includes Si with Ca and P. A result of osteoblast-like cellular proliferation on the membrane showed no cell-toxicity.

Info:

Periodical:

Key Engineering Materials (Volumes 309-311)

Main Theme:

Edited by:

Takashi Nakamura, Kimihiro Yamashita and Masashi Neo

Pages:

775-778

DOI:

10.4028/www.scientific.net/KEM.309-311.775

Citation:

H. Maeda et al., "Preparation of Poly(Lactic Acid) Hybrid Membranes Containing Silica", Key Engineering Materials, Vols. 309-311, pp. 775-778, 2006

Online since:

May 2006

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Price:

$35.00

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