Bioactive Bone Cements Containing Micron-Sized Titania Particles

Abstract:

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Three types of polymethylmethacrylate (PMMA)-based composite cements containing 40− 56 wt% micron-sized titania (titanium oxide) particles, designated ST2-40c, ST2-50c, and ST2-56c, were developed as bone substitutes for vertebroplasty, and evaluated for their mechanical, setting, and biological properties. In animal experiments, ST2-50c and ST2-56c were implanted into rat tibiae and solidified in situ. Their biological properties were evaluated at 6 and 12 weeks after implantation. Compressive strength, bending strength, and bending modulus increased with increasing titania content. Peak temperature during the setting reaction decreased as the filler content increased. ST2-56c had direct contact with bone over larger areas than ST2-50c at 6 and 12 weeks. Data from the present study indicated that ST2-56c is a good candidate as a bone substitute for vertebroplasty.

Info:

Periodical:

Key Engineering Materials (Volumes 309-311)

Main Theme:

Edited by:

Takashi Nakamura, Kimihiro Yamashita and Masashi Neo

Pages:

793-796

DOI:

10.4028/www.scientific.net/KEM.309-311.793

Citation:

K. Goto et al., "Bioactive Bone Cements Containing Micron-Sized Titania Particles", Key Engineering Materials, Vols. 309-311, pp. 793-796, 2006

Online since:

May 2006

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Price:

$35.00

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