Incorporation of 2nd and 3rd Generation Bisphosphonates on Hydroxyfluorapatite

Luis M. Rodríguez-Lorenzo; Blanca Vázquez; Julio San Román; Kārlis A. Gross

doi:10.4028/www.scientific.net/KEM.309-311.899

Paper Titles

The Effect of Hydroxyapatite on Bonding Strength in Light Curing Glass Ionomer Dental Cement
p.881

A Comparison of the Bone-Like Apatite Formation Potency Between Hydroxyapatite and β-Tricalcium Phosphate in Glass Ionomer Dental Luting Cement
p.885

Chemical Composition and Mechanical Properties of Bio-Derived Compact Bone Scaffolds
p.891

Surface Properties and Cytocompatibility of Bio-derived Compact Bone as Scaffolds for Tissue Engineering Bone
p.895

Incorporation of 2^nd and 3^rd Generation Bisphosphonates on Hydroxyfluorapatite
p.899

Calcium Phosphate Microspheres for Localised Delivery of a Therapeutic Enzyme
p.903

Starch-Based Microparticles as a Novel Strategy for Tissue Engineering Applications
p.907

MCM-41 /PCL Coated Hydroxyapatite and its Application to Drug Delivery System
p.911

Double Layered Microshells Composed of Calcium Phosphate and Poly (lactic acid)
p.915

HomeKey Engineering MaterialsKey Engineering Materials Vols. 309-311Incorporation of 2nd and 3rd Generation...

Incorporation of 2^nd and 3^rd Generation Bisphosphonates on Hydroxyfluorapatite

Abstract:

Bisphosphonates (BPs) may play an important role in minimizing osteolysis. In this work two new bisphosphonates pertaining to second and third generations respectively, have been synthesized and incorporated onto a chemically enriched hydroxyapatite. BP synthesis has been performed by adding H3PO3, PCl3 and methanesulfonic acid over 4-aminophenyl acetic acid (APBP) and 1-H-indole-3-acetic acid (IBP) respectively at 65°C in a N2 atmosphere. These compounds bear a primary amine group bonded to an aromatic ring, and a secondary amine group within a heterocyclic ring respectively. A chemically enriched hydroxyapatite with a chemical content corresponding to a 50% fluorided hydroxyapatite has been synthesized. Ceramic bodies manufactured by uniaxial pressure followed by cold isostatic press have a 97% density and submicron grain size. The BP was adsorbed onto the surface by immersion in a stirred solution at 37°C for 48 hours. A 10-fold decrease of the surface energy was observed for bodies modified with the APBP whereas only a 25 % decrease is obtained for bodies loaded with the bisphosphonate loaded with the IBP.