MCM-41 /PCL Coated Hydroxyapatite and its Application to Drug Delivery System
Porous hydroxyapatite coated with MCM-41/PCL has been utilized as the matrix for controlled drug delivery. SEM result shows porous hydroxyapatite block is formed of three dimensionally inter-connected pores of 250 –300 *m in size, similar to human cancellous bone. TEM observation confirms the pore size of MCM-41 scatters about 50 Å. Ibuprofen was loaded into the pores of MCM-41 and hybridized with polycaprolactone to coat on the surface of hydroxyapatite block and controlled release profiles were studied by soaking the samples in a simulated body fluid using a UV-VIS spectrophotometer.
Takashi Nakamura, Kimihiro Yamashita and Masashi Neo
Y. Kim et al., "MCM-41 /PCL Coated Hydroxyapatite and its Application to Drug Delivery System ", Key Engineering Materials, Vols. 309-311, pp. 911-914, 2006