MCM-41 /PCL Coated Hydroxyapatite and its Application to Drug Delivery System

Y. Kim; Kyung Ja Kim; Soo Ryong Kim; Hyo Won Lee

doi:10.4028/www.scientific.net/KEM.309-311.911

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 309-311MCM-41 /PCL Coated Hydroxyapatite and its...

MCM-41 /PCL Coated Hydroxyapatite and its Application to Drug Delivery System

Abstract:

Porous hydroxyapatite coated with MCM-41/PCL has been utilized as the matrix for controlled drug delivery. SEM result shows porous hydroxyapatite block is formed of three dimensionally inter-connected pores of 250 –300 *m in size, similar to human cancellous bone. TEM observation confirms the pore size of MCM-41 scatters about 50 Å. Ibuprofen was loaded into the pores of MCM-41 and hybridized with polycaprolactone to coat on the surface of hydroxyapatite block and controlled release profiles were studied by soaking the samples in a simulated body fluid using a UV-VIS spectrophotometer.

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Periodical:

Key Engineering Materials (Volumes 309-311)

Pages:

911-914

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.309-311.911

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Online since:

May 2006

Authors:

Y. Kim, Kyung Ja Kim, Soo Ryong Kim, Hyo Won Lee

Keywords:

Drug Delivery System, Hydroxyapatite (HAP), Ibuprofen, MCM-41, Polycaprolactone

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