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Innovative Technique for the Preparation of Porous Bilayer Hydroxyapatite/Chitosan Scaffolds for Osteochondral Applications

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Abstract:

In this study, it is shown that it is possible to develop 3D-porous bilayer hydroxyapatite/chitosan scaffolds by means of combining a sintering and a freeze-drying technique. Scanning electron microscopy (SEM/EDS) studies revealed that the scaffolds possess a well-defined orientation and anisotropic porosity, with pore size ranging between 50-350 µm. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) patterns evidenced the formation of crystalline hydroxyapatite. Moreover, the compression tests revealed that these scaffolds have adequate mechanical properties for being used in tissue engineering of osteochondral defects.

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Periodical:

Key Engineering Materials (Volumes 309-311)

Pages:

927-930

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.309-311.927

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Online since:

May 2006

Authors:

J. Miguel Oliveira, S.S. Silva, João F. Mano, Rui L. Reis

Keywords:

Bilayer Scaffolds, Chitosan (CS), Hydroxyapatite (HAP), Osteochondral Applications

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© 2006 Trans Tech Publications Ltd. All Rights Reserved

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