Innovative Technique for the Preparation of Porous Bilayer Hydroxyapatite/Chitosan Scaffolds for Osteochondral Applications
In this study, it is shown that it is possible to develop 3D-porous bilayer hydroxyapatite/chitosan scaffolds by means of combining a sintering and a freeze-drying technique. Scanning electron microscopy (SEM/EDS) studies revealed that the scaffolds possess a well-defined orientation and anisotropic porosity, with pore size ranging between 50-350 µm. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) patterns evidenced the formation of crystalline hydroxyapatite. Moreover, the compression tests revealed that these scaffolds have adequate mechanical properties for being used in tissue engineering of osteochondral defects.
Takashi Nakamura, Kimihiro Yamashita and Masashi Neo
J. M. Oliveira et al., "Innovative Technique for the Preparation of Porous Bilayer Hydroxyapatite/Chitosan Scaffolds for Osteochondral Applications", Key Engineering Materials, Vols. 309-311, pp. 927-930, 2006