Hyperstructured Hydroxyapatite Ceramics as a Carrier for Cell and Protein

Yoshiyuki Yokogawa; Sindhu Seelan; Yin Zhang

doi:10.4028/www.scientific.net/KEM.309-311.939

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 309-311Hyperstructured Hydroxyapatite Ceramics as a...

Hyperstructured Hydroxyapatite Ceramics as a Carrier for Cell and Protein

Abstract:

The preparation of hyperstructured hydroxyapatite (HAp) ceramics is reported. Mesoporous silica with nano size pore was coated on the bi-modal type porous HAp ceramics with pore size 100-200 µm and 1-2 µm. The mesoporous silica coating was done using two different procedures and the ceramics were characterized by XRD, N2 Sorption, SEM/EDX, and TEM. The results clearly showed the formation of mesoporous coating on the large pores of parent HAp ceramics. SEM images reveal that the mesoporous coatings consists of almost spherical particles with relatively uniform sizes of ~1 µm. Protein adsorption and release behavior on these mesoporous coated HAp ceramics was evaluated using UV-VIS spectrometry. The large pores are suitable for cell immobilization, and the mesopores several nm in size were found to enhance protein encapsulation ability.

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Periodical:

Key Engineering Materials (Volumes 309-311)

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939-942

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.309-311.939

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Online since:

May 2006

Authors:

Yoshiyuki Yokogawa, Sindhu Seelan, Yin Zhang

Keywords:

Hydroxyapatite (HAP), Hyperstructure, Mesoporous Coating, Protein Immobilization

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