Local Delivery of Antibiotics Using Hydroxyapatite with Bi-modal Pore Size Distribution

Masahiro Hasegawa; Akihiro Sudo; Vladimir S. Komlev; Sergej M. Barinov; Atsumasa Uchida

doi:10.4028/www.scientific.net/KEM.309-311.949

Paper Titles

Effects of Crude Bone Morphogenetic Protein and Pulp-Capping Materials on Rat Dental Pulp Cell Proliferation and Calcification In Vitro
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Porous Apatite Carrier Prepared by Hydrothermal Method
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Hyperstructured Hydroxyapatite Ceramics as a Carrier for Cell and Protein
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Fabrication and Characterization of Nano-Hydroxyapatite / Poly (D, L-lactide) Composite Porous Scaffolds for Human Cartilage Tissue Engineering
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Local Delivery of Antibiotics Using Hydroxyapatite with Bi-modal Pore Size Distribution
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Nano-Calcium Phosphate/PLLA Incorporated with bFGF as In Situ-Transplantable Carrier for Cartilage Regeneration
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Mechanical Behavior of Complex 3D Calcium Phosphate Cement Scaffolds Fabricated by Indirect Solid Freeform Fabrication In Vivo
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Blood Permeability of a Novel Ceramic Scaffold for BMP-2
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BMP-2 Dose-Response and Release Studies in Functionally Graded HAp
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Local Delivery of Antibiotics Using Hydroxyapatite with Bi-modal Pore Size Distribution

Abstract:

A novel hydroxyapatite (HA-A) was developed and we evaluated the slow release of antibiotic in vitro as well as osteoconduction of the material in vivo. HA-A (4 x 4 mm) was synthesized by mixing HA powder, gelatin, and vegetable oil. The material had a bi-modal pore size distribution, with intragranular (10 nm to 10 µm) and intergranular (100 µm) pores, and porosity of 40 vol%, while a control HA had pore sizes ranging from 50 to 300 µm and identical porosity. In vitro drug release was tested using antibiotics soaked on the HA cylinders using a vacuum system. The mean adsorption efficiency was higher for HA-A than for control and higher levels of antibiotic were released from HA-A. Bone ingrowth into the pores was observed for both materials. Since the novel HA showed both the slower release of antibiotic (nanosize pores) and supported excellent osteoconduction (microsize pores), it could be useful for the treatment of osteomyelitis.