Mechanical Behavior of Complex 3D Calcium Phosphate Cement Scaffolds Fabricated by Indirect Solid Freeform Fabrication In Vivo

Abstract:

Calcium phosphate cement is a bioceramic with potential applications for bone-tissue engineering. In this work, controlled porous calcium phosphate scaffolds with interconnected pores were computationally designed by an image-based approach and fabricated by indirect solid freeform fabrication (ISFF) or ‘lost mold’ technique. Voxel finite-element analysis (FEA) showed that mechanical properties of design and fabricated scaffold can be predicted computationally. Scaffolds were then implanted subcutaneously to demonstrate tissue in-growth. Previously, we showed the ability of porous calcium phosphate cement scaffolds to have sufficiently strong mechanical properties for bone tissue engineering applications. This work shows the image-based FEAs from micro-CT scans in vivo (four- and eight weeks). Extensive new bone apposition was noted with micro-CT technique after four- and eight weeks. FEA models of the original design and scaffolds with newly bone formed were compared.

• Periodical: Key Engineering Materials (Volumes 309-311)
• Pages: 957-960
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.309-311.957
• Online since: May 2006
• Authors: Leenaporn Jongpaiboonkit, C.Y. Lin, P.H. Krebsbach, S.J. Hollister, J.W. Halloran
• Keywords: Bone Tissue Engineering, Calcium Phosphate Cement (CPC), Micro-Compute Tomography, Scaffold, Solid Freeform Fabrication, Voxel-Based Finite Element

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