In Vitro Studies of Inflammation and Contact Activation of Titanium Oxide Film

An Sha Zhao; Ping Yang; Yong Xiang Leng; Jun Ying Chen; Jin Wang; Guo Jiang Wan; Nan Huang

doi:10.4028/www.scientific.net/KEM.330-332.729

Paper Titles

Surface Charge of Hydroxyapatite and Bone Mineral
p.713

In Situ Monitoring the Growth of HAP Crystal on the Surface of Ti/TiO₂in SBF with a Quartz Crystal Microbalance
p.717

Biomimetic Synthesis of the Nanocomposite of Phosphorylatd Chitosan and Hydroxyapatite and its Bioactivity In Vitro
p.721

Carbonate Substitution and Preferred Growth Orientation of Biomimetic Apatites
p.725

In Vitro Studies of Inflammation and Contact Activation of Titanium Oxide Film
p.729

Comparisons of the Apatite Presentation and Demineralization in Enamel and Cementum by Atomic Force Microscopy
p.733

Calcium Titanate Film-Coating on Titanium with Hydrothermal Treatments
p.737

Collagenous Molecule Immobilization on Hydroxyapatite Surface
p.741

Chemical Treatment for Inducing Bioactivity of TiO₂ Coating
p.745

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In Vitro Studies of Inflammation and Contact Activation of Titanium Oxide Film

Abstract:

Ti-O film is a kind of potential biomaterial may be applied in medical devices. But the mechanism of its good biocompatility is not so clear. This study revealed that when Titanium oxide contact with macrophage and plasma, the activation, adhesion and secretion of inflammatory molecule MCP-1 of macrophage is lower than reference material. Ti-O film also show minor contact activation to plasma. So reducing the host reaction including contact activation and inflammation may be the important reason for the good biocompatibility of Ti-O film.