The Effect of Lif-Maleic Acid Added Calcium Aluminate Bone Cement and Ca-PMMA Composite Bone Cement on Bone Regeneration in Rat Calvarial Defects

Abstract:

The purpose of this study was to evaluate histologically the effect of LiF-maleic acid added calcium aluminate (LM-CA) bone cement and calcium aluminate-polymethylmethacrylate (CA-PMMA) composite bone cement on bone regeneration in rat calvarial defect. After calvarial defects in 8 mm in diameter were created, three groups of 10 animals, a total of 30, each either received LM-CA bone cement, CA-PMMA composite bone cement or a sham-surgery control. Histologic analysis was done at 2 weeks and 8 weeks of healing periods. We concluded that LM-CA bone cement can be used as a bioactive bone graft material due to ability of bonding to the existing bone and CA-PMMA can be used as a graft material for augmentation of bone-volume due to dimensional stability.

• Periodical: Key Engineering Materials (Volumes 330-332)
• Pages: 851-854
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.330-332.851
• Online since: February 2007
• Authors: Ui Won Jung, J.A. Shin, K.J. Chae, Yong Keun Lee, Chong Kwan Kim, Seong Ho Choi
• Keywords: Bone Cement, Bone Graft Material, Bone Regeneration, Calvarial Defect

References

[1] L. L. Hench, R. J. Splinter, W. C. Allen et al. J Biomed Mater Res Vol. 2(1971), p.117.

[2] J. J. Klawitter, S. F. Hulbert. J Biomed Mater Res Voi. 2 (1971), p.161.

[3] W. F. Mousa, M. Kobayashi, S. Shinzato, et al. Biomaterials Vol. 21(2000), p.2137.

[4] S. Shinzato, M. Kobayashi, W. F. Mousa, et al. (2000) J Biomed Mater Res Vol. 51(2000), p.258.