Investigation on the Biomimetic Scaffold for Bone Tissue Engineering Based on Bioglass-Collagen-Hyaluronic Acid-Phosphatidylserine

Abstract:

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The new type of bone tissue engineering scaffold composed of the sol-gel derived bioactive glass particles, type I collagen, hyaluronic acid and phosphatidylserine were prepared through cross-linking and freeze-drying techniques. SEM observation indicated that the scaffold possessed a 3-D interconnected porous structure and a high porosity. The properties of bio-mineralization and cells biocompatibility were investigated using SBF immersion and cells culture methods combined with SEM, XRD and FTIR techniques. The study revealed that this biomimetic scaffold possessed satisfactory functions of cells attachment, bio-mineralization, and cells biocompatibility. The porous structure and the surface of the scaffold which was covered by a bone-like HA crystal layer due to bio-mineralization were profitable for cells attachment and spread.

Info:

Periodical:

Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu

Pages:

939-942

DOI:

10.4028/www.scientific.net/KEM.330-332.939

Citation:

X. F. Chen et al., "Investigation on the Biomimetic Scaffold for Bone Tissue Engineering Based on Bioglass-Collagen-Hyaluronic Acid-Phosphatidylserine", Key Engineering Materials, Vols. 330-332, pp. 939-942, 2007

Online since:

February 2007

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$38.00

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