Formation of Apatite within Biodegradable Scaffolds by an Accelerated Biomimetic Process in the Shaking Condition and Flow Condition
Bonelike apatite coating was formed on poly(L-lactic acid) (PLLA) scaffolds and poly(glycolic acid) (PGA) scaffolds in 24 hours through an accelerated biomimetic process. The ion concentrations in the simulated body fluid (SBF) were nearly 5 times of those in human blood plasma. The apatite formed in 5SBF was similar in morphology and composition to that formed in the classical biomimetic process employing SBF or 1.5SBF, and similar to that of natural bone. To facilitate coating into scaffolds, the flowing condition was introduced into the accelerated biomimetic process. It was found that the accelerated biomimetic process performed in the flowing condition yielded more uniform spatial distribution of apatite particles than that in the regular shaking condition.
J.K. Kim, D.Z. Wo, L.M. Zhou, H.T. Huang, K.T. Lau and M. Wang
Y. Chen et al., "Formation of Apatite within Biodegradable Scaffolds by an Accelerated Biomimetic Process in the Shaking Condition and Flow Condition", Key Engineering Materials, Vols. 334-335, pp. 1213-1216, 2007