Investigation on the Porous Biomaterial for Bone Reconstruction with Addition of Bio-Mimetic Nano-Sized Inorganic Particles

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The spherical nano-sized bioactive particles in the system of CaO-P2O5-SiO2 were bio-mimetically synthesized using micro-emulsion method. The microstructures and properties of the bio- mimetic nano-materials were characterized using XRD, FTIR, SEM/EDAX and TEM techniques. It was indicated that the nano-particles possessed glassy structural characteristics. The porous composite for bone tissue reconstruction was prepared by compounding poly (hydroxybutyrate-2-co-2-hydroxyvalerate) (PHBV) and the nano-particles of bio-mimetic bioactive glasses (BMBG). Bone-like hydroxyl- carbonate-apatite (HCA) could formed on the surface of porous composite by immersing the composite in simulated body fluid (SBF) at 37°C for 8 hours. With increase of immersion time, the morphology of HCA changed from spherical into flake-like crystals. The study on cells attachment of the porous PHBV/BMBG composite proved that the material possessed satisfactory bioactivity, bio-mineralization function and cells biocompatibility.

Info:

Periodical:

Key Engineering Materials (Volumes 336-338)

Edited by:

Wei Pan and Jianghong Gong

Pages:

1534-1537

DOI:

10.4028/www.scientific.net/KEM.336-338.1534

Citation:

H. D. Zheng et al., "Investigation on the Porous Biomaterial for Bone Reconstruction with Addition of Bio-Mimetic Nano-Sized Inorganic Particles", Key Engineering Materials, Vols. 336-338, pp. 1534-1537, 2007

Online since:

April 2007

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$35.00

[1] M. Uota, H. Arakawa, N. Kitamura, et al.: Langmuir Vol. 21 (2005), p.4724.

[2] S. Bose, S.K. Saha: Chem. Mater. Vol. 15 (2003), p.4464.

[3] L. Wang, R. Nemoto and M. Senna: J. Nanoparticle Research Vol. 6 (2004), p.91.

[4] F. Chen, Z.C. Wang, C.J. Lin: Mater. Lett. Vol. 57 (2002), p.858.

[5] A.S. Milev, G. S. Kamali Kannangara and M.A. Wilson: Langmuir Vol. 20 (2004), p.1888.

[6] A. Cüneyt Tas: Biomaterials Vol. 21 (2000), p.1429.

[7] T. Kokubo, H.M. Kim, M. Kawashita: Biomaterials Vol. 24 (2003), p.2161.

[8] N. Costa a, P.M. Maquis: Medical Engineering & Physics Vol. 20 (1998), p.602. b a.

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