Investigation on the Porous Biomaterial for Bone Reconstruction with Addition of Bio-Mimetic Nano-Sized Inorganic Particles
The spherical nano-sized bioactive particles in the system of CaO-P2O5-SiO2 were bio-mimetically synthesized using micro-emulsion method. The microstructures and properties of the bio- mimetic nano-materials were characterized using XRD, FTIR, SEM/EDAX and TEM techniques. It was indicated that the nano-particles possessed glassy structural characteristics. The porous composite for bone tissue reconstruction was prepared by compounding poly (hydroxybutyrate-2-co-2-hydroxyvalerate) (PHBV) and the nano-particles of bio-mimetic bioactive glasses (BMBG). Bone-like hydroxyl- carbonate-apatite (HCA) could formed on the surface of porous composite by immersing the composite in simulated body fluid (SBF) at 37°C for 8 hours. With increase of immersion time, the morphology of HCA changed from spherical into flake-like crystals. The study on cells attachment of the porous PHBV/BMBG composite proved that the material possessed satisfactory bioactivity, bio-mineralization function and cells biocompatibility.
Wei Pan and Jianghong Gong
H. D. Zheng, Y. J. Wang, C. R. Yang, X. F. Chen, N. R. Zhao, "Investigation on the Porous Biomaterial for Bone Reconstruction with Addition of Bio-Mimetic Nano-Sized Inorganic Particles", Key Engineering Materials, Vols. 336-338, pp. 1534-1537, 2007