Investigation on the Porous Biomaterial for Bone Reconstruction with Addition of Bio-Mimetic Nano-Sized Inorganic Particles
The spherical nano-sized bioactive particles in the system of CaO-P2O5-SiO2 were bio-mimetically synthesized using micro-emulsion method. The microstructures and properties of the bio- mimetic nano-materials were characterized using XRD, FTIR, SEM/EDAX and TEM techniques. It was indicated that the nano-particles possessed glassy structural characteristics. The porous composite for bone tissue reconstruction was prepared by compounding poly (hydroxybutyrate-2-co-2-hydroxyvalerate) (PHBV) and the nano-particles of bio-mimetic bioactive glasses (BMBG). Bone-like hydroxyl- carbonate-apatite (HCA) could formed on the surface of porous composite by immersing the composite in simulated body fluid (SBF) at 37°C for 8 hours. With increase of immersion time, the morphology of HCA changed from spherical into flake-like crystals. The study on cells attachment of the porous PHBV/BMBG composite proved that the material possessed satisfactory bioactivity, bio-mineralization function and cells biocompatibility.
Wei Pan and Jianghong Gong
H. D. Zheng et al., "Investigation on the Porous Biomaterial for Bone Reconstruction with Addition of Bio-Mimetic Nano-Sized Inorganic Particles", Key Engineering Materials, Vols. 336-338, pp. 1534-1537, 2007