Investigation on the Porous Biomaterial for Bone Reconstruction with Addition of Bio-Mimetic Nano-Sized Inorganic Particles

Abstract:

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The spherical nano-sized bioactive particles in the system of CaO-P2O5-SiO2 were bio-mimetically synthesized using micro-emulsion method. The microstructures and properties of the bio- mimetic nano-materials were characterized using XRD, FTIR, SEM/EDAX and TEM techniques. It was indicated that the nano-particles possessed glassy structural characteristics. The porous composite for bone tissue reconstruction was prepared by compounding poly (hydroxybutyrate-2-co-2-hydroxyvalerate) (PHBV) and the nano-particles of bio-mimetic bioactive glasses (BMBG). Bone-like hydroxyl- carbonate-apatite (HCA) could formed on the surface of porous composite by immersing the composite in simulated body fluid (SBF) at 37°C for 8 hours. With increase of immersion time, the morphology of HCA changed from spherical into flake-like crystals. The study on cells attachment of the porous PHBV/BMBG composite proved that the material possessed satisfactory bioactivity, bio-mineralization function and cells biocompatibility.

Info:

Periodical:

Key Engineering Materials (Volumes 336-338)

Edited by:

Wei Pan and Jianghong Gong

Pages:

1534-1537

DOI:

10.4028/www.scientific.net/KEM.336-338.1534

Citation:

H. D. Zheng, Y. J. Wang, C. R. Yang, X. F. Chen, N. R. Zhao, "Investigation on the Porous Biomaterial for Bone Reconstruction with Addition of Bio-Mimetic Nano-Sized Inorganic Particles", Key Engineering Materials, Vols. 336-338, pp. 1534-1537, 2007

Online since:

April 2007

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$35.00

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