Investigation on the Porous Biomaterial for Bone Reconstruction with Addition of Bio-Mimetic Nano-Sized Inorganic Particles

Hua De Zheng; Ying Jun Wang; Chun Rong Yang; Xiao Feng Chen; Na Ru Zhao

doi:10.4028/www.scientific.net/KEM.336-338.1534

Paper Titles

Microstructure and Properties of (Ti,W)(C,N)/(Ni,Mo) Cermets after a Heat-Treatment at High Nitrogen Pressure
p.1521

Effect of Cr₂C₃ Addition on Microstructure and Mechanical Properties of Ti(CN)-Based Cermets
p.1524

Residual Stress Field of Ellipsoidal Ceramic Particles Ni-Base Alloy Composite Coating
p.1527

FEM Analysis on Thermal Stress of Desulphurization Injection Lance
p.1531

Investigation on the Porous Biomaterial for Bone Reconstruction with Addition of Bio-Mimetic Nano-Sized Inorganic Particles
p.1534

Inhibitory Effect of Synthetic Nano-Hydroxyapatite on Dental Caries
p.1538

Apatite Formation on the Surface of Dense HA/TCP in Animals' Serums
p.1542

In Vitro Degradation of β-TCP/PLLA Scaffolds with Different Proportions of β-TCP
p.1545

Application of Multilayer Collagen/HA Scaffold in Cartilage Tissue Engineering
p.1549

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Investigation on the Porous Biomaterial for Bone Reconstruction with Addition of Bio-Mimetic Nano-Sized Inorganic Particles

Abstract:

The spherical nano-sized bioactive particles in the system of CaO-P2O5-SiO2 were bio-mimetically synthesized using micro-emulsion method. The microstructures and properties of the bio- mimetic nano-materials were characterized using XRD, FTIR, SEM/EDAX and TEM techniques. It was indicated that the nano-particles possessed glassy structural characteristics. The porous composite for bone tissue reconstruction was prepared by compounding poly (hydroxybutyrate-2-co-2-hydroxyvalerate) (PHBV) and the nano-particles of bio-mimetic bioactive glasses (BMBG). Bone-like hydroxyl- carbonate-apatite (HCA) could formed on the surface of porous composite by immersing the composite in simulated body fluid (SBF) at 37°C for 8 hours. With increase of immersion time, the morphology of HCA changed from spherical into flake-like crystals. The study on cells attachment of the porous PHBV/BMBG composite proved that the material possessed satisfactory bioactivity, bio-mineralization function and cells biocompatibility.