Fabrication and Characterization of Hydrophilized Polydioxanone Scaffolds for Tissue Engineering Applications

Abstract:

Porous polydioxanone (PDO)/polyvinyl alcohol (PVA) scaffolds were fabricated by blending PDO with a small amount of PVA to improve the hydrophilicity and cell/tissue compatibility of the scaffolds for tissue engineering applications. PDO/PVA scaffolds with different PVA compositions up to 10 wt% were fabricated by a melt-molding particulate-leaching method (non-solvent method). The prepared scaffolds exhibited highly porous, uniform open-cellular pore structures. The PDO/PVA scaffolds with PVA compositions more than 5 % were easily wetted in cell culture medium. The hydrophilized PDO/PVA (5 wt%) scaffold showed better cell adhesion and growth than the control hydrophobic PDO scaffold. The PDO/PVA (5 wt%) scaffold also showed faster tissue infiltration into the scaffold than the PDO scaffold. It seems that 5 wt% addition of PVA to PDO to fabricate PDO/PVA scaffolds is enough for improving the hydrophilicity and cell/tissue compatibility of the scaffolds.

• Periodical: Key Engineering Materials (Volumes 342-343)
• Pages: 289-292
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.342-343.289
• Online since: July 2007
• Authors: Kwang Joon Cho, Dae Keun Song, Se Heang Oh, Young Joo Koh, Sahng Hoon Lee, Myung Chul Lee, Jin Ho Lee
• Keywords: Cell/Tissue Compatibility, Hydrophilicity, Poly(vinyl alcohol), Polydioxanone (PDO), Porous Scaffold, Tissue Engineering

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