Biodegradable Porous PCL/HA Scaffolds for Bone Tissue Engineering

Seung Eon Kim; Yong Taek Hyun; Dong June Chung; S.J. Heo; Jung Woog Shin; J.H. Lee

doi:10.4028/www.scientific.net/KEM.342-343.77

Paper Titles

Tissue Regeneration of a Hybrid Vascular Graft Composed of Biodegradable Layers and Non-Biodegradable Layer by Static and Pulsatile Flows
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A Novel Method for Porous Chitosan Scaffold
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Preparation and Characterization of Small Intestinal Submucosa Coated with Alginate/Gelatin as a Wound Dressing
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The Biocompatibility of Silk Scaffold for Tissue Engineered Ligaments
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Biodegradable Porous PCL/HA Scaffolds for Bone Tissue Engineering
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Toxicity Test of Wound Covering Material on Animals
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Observation of Proliferation and Attachment of Three Different Cell Types on Nano-Fibrous Silk Film & Scaffold
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Human Cartilage Tissue Engineering with Pluronic and Cultured Chondrocyte Sheet
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Growth of Smooth Muscle Cell and Endothelial Cell on PLGA Film Containing EGCG
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HomeKey Engineering MaterialsKey Engineering Materials Vols. 342-343Biodegradable Porous PCL/HA Scaffolds for Bone...

Biodegradable Porous PCL/HA Scaffolds for Bone Tissue Engineering

Abstract:

Poly ε-caprolactone(PCL)/hydroxyapatite(HA) composite scaffolds were fabricated by particulate leaching and freeze drying routes with different HA content. Porosity was decreased with HA addition, while mean pore size was maintained at around porogen size regardless of HA content. Compressive modulus was increased with increasing HA content. In this study, the optimum content of HA was around 40% in weight against PCL to obtain the highest compressive modulus with keeping porosity above 85%. HA apparently enhanced proliferation of osteoblast-like MG63 cells in PCL/HA composite scaffolds. Typical adhesion, migration and aggregation procedure of MG63 cells were found on PCL, while spreading morphology only was found on HA even at the early stage of adhesion without migration or aggregation.

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Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

77-80

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.77

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Online since:

July 2007

Authors:

Seung Eon Kim, Yong Taek Hyun, Dong June Chung, S.J. Heo, Jung Woog Shin, J.H. Lee

Keywords:

Cell Adhesion, Compressive Modulus, MTT, PCL/HA Scaffolds, Tissue Engineering

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