In Vitro Studies of Cell Growth on Three Differently Fabricated Hydroxyapatite Ceramic Scaffolds for Bone Tissue Engineering

Rainer Detsch; Franzika Uhl; Ulrike Deisinger; Günter Ziegler

doi:10.4028/www.scientific.net/KEM.361-363.1181

Paper Titles

Reconstruction of Liver Organoid Using an Apatite-Fiber Scaffold, a Radial-Flow Bioreactor and FCL-4 Cells of Hepatocyte Model
p.1165

Behavior of Cellularized-Hydroxyapatite Implants Coated with Cyclo-DfKRG Peptides in Spongious Bone: Quantitative Comparison of Micro-Tomodensitometry and Histomorphometry
p.1169

Expression of ODF and ICAM-1 of Bone Marrow Mesenchymal Stem Cells is Enhanced with Osteogenic Differentiation
p.1173

Stimulatory Effect of Nano-Sized Calcium Metaphosphate Particles on Proliferation and Osteoblastic Differentiation of Human Bone Marrow Mesenchymal Stem Cells
p.1177

In Vitro Studies of Cell Growth on Three Differently Fabricated Hydroxyapatite Ceramic Scaffolds for Bone Tissue Engineering
p.1181

In Vivo Osteogenesis in Porous Hydroxyapatite Scaffold Processed in Hyaluronic Acid Solution
p.1185

Osteogenic Influence of Lysine in Porous Hydroxyapatite Scaffold
p.1189

Antibacterial Activity of Silver-Doped Glasses and Glass-Ceramics
p.1195

Fabrication of Encapsulated Ag Microsphere with Hydroxyapatite for Sustained-Release
p.1199

HomeKey Engineering MaterialsKey Engineering Materials Vols. 361-363In Vitro Studies of Cell Growth on Three...

In Vitro Studies of Cell Growth on Three Differently Fabricated Hydroxyapatite Ceramic Scaffolds for Bone Tissue Engineering

Abstract:

The aim of this study is to analyse the influence of differently fabricated HA-scaffolds on bone marrow stromal cells. Therefore, three methods were used (a polyurethane (PU)-replica technique, the dispense-plotting and a negative mould technique) to produce porous hydroxyapatite (HA) ceramics. The different HA-scaffolds were then cultivated with an osteoblastic precursor cell line. In our study, highest cell proliferation and differentiation was achieved by using (PU)-replica technique. However, this study shows also that all three types of scaffolds are suitable for tissue engineering applications and as bone substitute material. The knowledge about the influence of pore size and geometry on the cell behaviour will help to tailor scaffolds, by different 3D fabrication methods, for the needs of tissue engineering laboratories or patients.

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Periodical:

Key Engineering Materials (Volumes 361-363)

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1181-1184

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.361-363.1181

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Online since:

November 2007

Authors:

Rainer Detsch, Franzika Uhl, Ulrike Deisinger, Günter Ziegler

Keywords:

Bone Cells, Calcium Phosphate Ceramic, Tissue Engineering

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