For Libraries For Publication Open Access Downloads About Us Contact Us
Paper Titles
Expression Patterns of Cell Surface Molecules on Human Bone Marrow Stromal Cells from Multi-Donors
p.1153
Mechanical Properties of Living Cells: Interaction of the Adherent Endothelial Cell and the Fluid Shear Flow
p.1157
Preliminary Study for Evaluating Bone Forming Ability of Porous Bioceramics Using Rat Mesenchymal Stem Cells to be Used for International Standard
p.1161
Reconstruction of Liver Organoid Using an Apatite-Fiber Scaffold, a Radial-Flow Bioreactor and FCL-4 Cells of Hepatocyte Model
p.1165
Behavior of Cellularized-Hydroxyapatite Implants Coated with Cyclo-DfKRG Peptides in Spongious Bone: Quantitative Comparison of Micro-Tomodensitometry and Histomorphometry
p.1169
Expression of ODF and ICAM-1 of Bone Marrow Mesenchymal Stem Cells is Enhanced with Osteogenic Differentiation
p.1173
Stimulatory Effect of Nano-Sized Calcium Metaphosphate Particles on Proliferation and Osteoblastic Differentiation of Human Bone Marrow Mesenchymal Stem Cells
p.1177
In Vitro Studies of Cell Growth on Three Differently Fabricated Hydroxyapatite Ceramic Scaffolds for Bone Tissue Engineering
p.1181
In Vivo Osteogenesis in Porous Hydroxyapatite Scaffold Processed in Hyaluronic Acid Solution
p.1185

Behavior of Cellularized-Hydroxyapatite Implants Coated with Cyclo-DfKRG Peptides in Spongious Bone: Quantitative Comparison of Micro-Tomodensitometry and Histomorphometry

Article Preview

Abstract:

In order to develop bone substitute with osteogenic properties, a novel strategy of grafting cyclo-DfKRG peptides to enhance cells adhesion and osteointegration of hydroxyapatite (HA) implants was developed. Objectives of the study were (1) to evaluate the osteogenic properties of HA implants grafted with RGD peptides and (2) to compare histomorphometry and micro-computed tomography ((CT) with bone quantification. Pure HA grafted or not with cyclo- DfKRG peptides and autologous stromal cells was implanted in femoral condyle on 2 groups (2 and 4 weeks) of 6 New Zealand rabbits. Measurements concerning bone reconstruction and material structure were obtained with a (CT and the results were compared to those obtained after histomorphometry. Finally, it appears that grafting cyclo-DfKRG on HA implants enhances nonsignificantly the rate of bone formation, and a high correlation of the results was found comparing histomorphometry and (CT analysis.

You might also be interested in these eBooks
Bioceramics 20 View Preview

Info:

Periodical:

Key Engineering Materials (Volumes 361-363)

Pages:

1169-1172

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.361-363.1169

Citation:

Cite this paper

Online since:

November 2007

Authors:

Jack Malinvaud, Sylvain Catros, L. Pothuaud, Reiner Bareille, Joelle Amédée, Jean Christophe Fricain

Keywords:

Histomorphometry, Hydroxyapatite (HAP), Micro Computed Tomography (μ-CT), New Bone Formation, RGD Peptide

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2008 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

References

[1] H Petite, V Viateau, W Bensaid: Nat Biotechnol. Vol. 18 (2002), p.959.

Google Scholar

[2] O Schultz, M Sittinger, T Haeupl: Arthritis research Vol. 6 (2000), pp.433-436.

Google Scholar

[3] R Marom, I Shur, R Solomon: J. Cell. Physiol. Vol. 202 (2005), pp.41-48.

Google Scholar

[4] JS Boo, Y Yamada, Y Okazaki: J. Craniofac. Surg. Vol. 13 (2002), p.231.

Google Scholar

[5] G Guillemin, M Launay: J. Mater. Sci. Mater. Med. Vol. 4 (1993), p.575.

Google Scholar

[6] Y Wang, T Uemura: Tissue Eng. Vol. 9 (2003), p.1205.

Google Scholar

[7] S Pallu, R Bareille, M Dard: Peptides Vol. 24 (2003), p.1349.

Google Scholar

[8] S Verrier, S Pallu: Biomaterials Vol. 23 (2002), p.585.

Google Scholar

[9] MC Porte-Durrieu, F Guillemot, S Pallu: Biomaterials Vol. 25 (2004), p.4837.

Google Scholar

[10] MC Durrieu, S Pallu, F Guillemot: J. Mater. Sci. Mater. Med. Vol. 15 (2004), p.779.

Google Scholar

[11] J Vilamitjana-Amédée, R Bareille, F Rouais : In Vitro Cell Dev. Biol. Anim. Vol. 29 (1993), p.699.

Google Scholar

[12] F Villars, R Bareille, L Bordenave: J. Cell. Biochem. Vol. 15 (2000), p.672.

Google Scholar

[13] E Wolf, K Roser, M Hahn: Archiv. Pathol. Anat. Histopathol. Vol. 420 (1992), p.17.

Google Scholar

[14] H Van Lenthe, H Hagenmüller, M Bohner: Biomaterials Vol. 28 (2007), pp.2479-2490.

Google Scholar

[15] L Pothuaud, JC Fricain, S Pallu: Biomaterials Vol. 26 (2005), pp.6788-6797.

Google Scholar

[16] EL Hedberg, HC Kroese-Deutman, CK Shih: Tissue Engineering Vol. 11 (2005), pp.1356-1367.

Google Scholar

[17] O Gauthier, R Müller, D Von Stechow: Biomaterials Vol. 26 (2005), pp.5444-5453.

Google Scholar

[18] C Chappard, B Brunet-Imbault, CL Benhamou-Erit: Synoviale Vol. 118 (2002).

Google Scholar

[19] R Müller, H Van Campenhout, B Van Damme: Bone Vol. 23 (1998), pp.59-66.

Google Scholar

[20] Y Germanier, S Tosatti, N Broggini: Clin. Oral. Implant Res. Vol. 17 (2006), pp.251-57.

Google Scholar

[21] S Rammelt, T Illert, S Bierbaum : Biomaterials Vol. 27 (2006), pp.5561-71.

Google Scholar

© 2025 Trans Tech Publications Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For open access content, terms of the Creative Commons licensing CC-BY are applied.
Scientific.Net is a registered trademark of Trans Tech Publications Ltd.