Behavior of Cellularized-Hydroxyapatite Implants Coated with Cyclo-DfKRG Peptides in Spongious Bone: Quantitative Comparison of Micro-Tomodensitometry and Histomorphometry

Abstract:

Article Preview

In order to develop bone substitute with osteogenic properties, a novel strategy of grafting cyclo-DfKRG peptides to enhance cells adhesion and osteointegration of hydroxyapatite (HA) implants was developed. Objectives of the study were (1) to evaluate the osteogenic properties of HA implants grafted with RGD peptides and (2) to compare histomorphometry and micro-computed tomography ((CT) with bone quantification. Pure HA grafted or not with cyclo- DfKRG peptides and autologous stromal cells was implanted in femoral condyle on 2 groups (2 and 4 weeks) of 6 New Zealand rabbits. Measurements concerning bone reconstruction and material structure were obtained with a (CT and the results were compared to those obtained after histomorphometry. Finally, it appears that grafting cyclo-DfKRG on HA implants enhances nonsignificantly the rate of bone formation, and a high correlation of the results was found comparing histomorphometry and (CT analysis.

Info:

Periodical:

Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle

Pages:

1169-1172

DOI:

10.4028/www.scientific.net/KEM.361-363.1169

Citation:

J. Malinvaud et al., "Behavior of Cellularized-Hydroxyapatite Implants Coated with Cyclo-DfKRG Peptides in Spongious Bone: Quantitative Comparison of Micro-Tomodensitometry and Histomorphometry", Key Engineering Materials, Vols. 361-363, pp. 1169-1172, 2008

Online since:

November 2007

Export:

Price:

$38.00

[1] H Petite, V Viateau, W Bensaid: Nat Biotechnol. Vol. 18 (2002), p.959.

[2] O Schultz, M Sittinger, T Haeupl: Arthritis research Vol. 6 (2000), pp.433-436.

[3] R Marom, I Shur, R Solomon: J. Cell. Physiol. Vol. 202 (2005), pp.41-48.

[4] JS Boo, Y Yamada, Y Okazaki: J. Craniofac. Surg. Vol. 13 (2002), p.231.

[5] G Guillemin, M Launay: J. Mater. Sci. Mater. Med. Vol. 4 (1993), p.575.

[6] Y Wang, T Uemura: Tissue Eng. Vol. 9 (2003), p.1205.

[7] S Pallu, R Bareille, M Dard: Peptides Vol. 24 (2003), p.1349.

[8] S Verrier, S Pallu: Biomaterials Vol. 23 (2002), p.585.

[9] MC Porte-Durrieu, F Guillemot, S Pallu: Biomaterials Vol. 25 (2004), p.4837.

[10] MC Durrieu, S Pallu, F Guillemot: J. Mater. Sci. Mater. Med. Vol. 15 (2004), p.779.

[11] J Vilamitjana-Amédée, R Bareille, F Rouais : In Vitro Cell Dev. Biol. Anim. Vol. 29 (1993), p.699.

[12] F Villars, R Bareille, L Bordenave: J. Cell. Biochem. Vol. 15 (2000), p.672.

[13] E Wolf, K Roser, M Hahn: Archiv. Pathol. Anat. Histopathol. Vol. 420 (1992), p.17.

[14] H Van Lenthe, H Hagenmüller, M Bohner: Biomaterials Vol. 28 (2007), pp.2479-2490.

[15] L Pothuaud, JC Fricain, S Pallu: Biomaterials Vol. 26 (2005), pp.6788-6797.

[16] EL Hedberg, HC Kroese-Deutman, CK Shih: Tissue Engineering Vol. 11 (2005), pp.1356-1367.

[17] O Gauthier, R Müller, D Von Stechow: Biomaterials Vol. 26 (2005), pp.5444-5453.

[18] C Chappard, B Brunet-Imbault, CL Benhamou-Erit: Synoviale Vol. 118 (2002).

[19] R Müller, H Van Campenhout, B Van Damme: Bone Vol. 23 (1998), pp.59-66.

[20] Y Germanier, S Tosatti, N Broggini: Clin. Oral. Implant Res. Vol. 17 (2006), pp.251-57.

[21] S Rammelt, T Illert, S Bierbaum : Biomaterials Vol. 27 (2006), pp.5561-71.

In order to see related information, you need to Login.