Fabrication of Encapsulated Ag Microsphere with Hydroxyapatite for Sustained-Release
Apatite nuclei were synthesized by raising pH of simulated body fluid (SBF). The apatite nuclei were attached to surfaces of Ag microspheres. Hydroxyapatite (HAp) was induced from the apatite nuclei and spread over whole surface area of the Ag microspheres in SBF, then encapsulated Ag microspheres with HAp were fabricated. The encapsulated Ag microspheres with HAp were soaked in saline and changes in Ag ion concentration in saline were measured. The encapsulated Ag microspheres with HAp showed sustained-release of Ag ion.
Guy Daculsi and Pierre Layrolle
T. Yabutsuka et al., "Fabrication of Encapsulated Ag Microsphere with Hydroxyapatite for Sustained-Release ", Key Engineering Materials, Vols. 361-363, pp. 1199-1202, 2008