Development of In Situ-Formed Interconnected Porous Scaffolds with Low Porosity

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Biocompatible and water-soluble fibers (sodium carboxymethyl cellulose (CMC)) were fabricated via a wet-spinning method. The CMC fibers/ polymethyl methacrylate (PMMA) mixtures and CMC fibers/Poly (L-lactide-co-glycolide-co- -caprolactone) (PLGC) mixtures were prepared by a heat-kneading method. For CMC fibers/PMMA, after removal of the CMC fibers from the mixtures, the interconnected porous scaffolds with porosity from 27.79 % to 60.98 % (volume percent) were obtained. For CMC fibers/PLGC, the interconnected porous scaffolds with porosity 38.55 % and 76.83 % (volume percent) were prepared. The solid CMC fibers/PLGC mixtures had the higher ultimate tensile strength and Young, s modulus than those of porous PLGC scaffolds.

Info:

Periodical:

Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle

Pages:

415-418

DOI:

10.4028/www.scientific.net/KEM.361-363.415

Citation:

Y. L. Li and M. Kikuchi, "Development of In Situ-Formed Interconnected Porous Scaffolds with Low Porosity", Key Engineering Materials, Vols. 361-363, pp. 415-418, 2008

Online since:

November 2007

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$38.00

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