Sol-Gel Synthesis and In Vitro Cell Compatibility Analysis of Silicate-Containing Biodegradable Hybrid Gels

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Novel hybrid gels in the system gelatin-GPTMS-TEOS were prepared via a sol-gel route, and their ability to release Si(IV) was examined using MG63 osteoblast-like cell culture. The amount of Si released and the release rate were controllable by changing the mixing ratio of GPTMS and TEOS. In addition, the hybrids had biocompatible surfaces. It is expected that the hybrids will be utilized for the investigation of the effect of Si on cell differentiation and tissue regeneration.

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Periodical:

Key Engineering Materials (Volumes 361-363)

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Edited by:

Guy Daculsi and Pierre Layrolle

Pages:

447-450

Citation:

K. Tsuru et al., "Sol-Gel Synthesis and In Vitro Cell Compatibility Analysis of Silicate-Containing Biodegradable Hybrid Gels", Key Engineering Materials, Vols. 361-363, pp. 447-450, 2008

Online since:

November 2007

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$38.00

[1] K. Tsuru et al., (1997) J. Mat. Sci.; Mat. Med., 8: 157.

[2] Y Shirosaki et al., (2005) Biomaterials, 26: 485.

[3] E. M. Carlisle (1972) Science, 178: 619.

[4] D. M. Reffitt et al. (2003) Bone, 32, 127.

[5] L. L. Hench (2004) Key Eng. Mat., 254-256: 3.

[6] N. Patel et al., (2002) J. Mat. Sci.: Mat. Med., 13: 1199.

[7] L. Ren et al., (2003) J. Sol-Gel Sci. Technol., 26, 1137. Figure 4. OCN/total DNA for PC (cells with no hybrid), hybrids A(GGP05), C(GGP05TE05), and at days 10, 13, 16.