Sol-Gel Synthesis and In Vitro Cell Compatibility Analysis of Silicate-Containing Biodegradable Hybrid Gels
Novel hybrid gels in the system gelatin-GPTMS-TEOS were prepared via a sol-gel route, and their ability to release Si(IV) was examined using MG63 osteoblast-like cell culture. The amount of Si released and the release rate were controllable by changing the mixing ratio of GPTMS and TEOS. In addition, the hybrids had biocompatible surfaces. It is expected that the hybrids will be utilized for the investigation of the effect of Si on cell differentiation and tissue regeneration.
Guy Daculsi and Pierre Layrolle
K. Tsuru et al., "Sol-Gel Synthesis and In Vitro Cell Compatibility Analysis of Silicate-Containing Biodegradable Hybrid Gels", Key Engineering Materials, Vols. 361-363, pp. 447-450, 2008