Preparation of Bioactive Poly(Lactic-Co-Glycolic)Acid and Silica Gel Fibers Mixed Non-Woven Fabric

Abstract:

Poly(lactic-co-glycolic)acid and silica gel fibers mixed non-woven fabric was made by electro-spinning method for the potential application as a bone grafting material. The silica gel, the source material for electro-spinning, was prepared by the hydrolysis of tetraethyl orthosilicate in the presence of calcium salt, water, hydrochloric acid and ethanol. Poly(lactic-co-glycolic)acid solution was prepared by dissolving it in the hexafluoroisopropanol. Then, they were transferred to two separate syringes which were connected to the high voltage supply generating a high electric field between the spinneret and the ground collecting drum. The silica gel containing calcium and poly(lactic-co-glycolic)acid solution were spun together under the electric field of 2 ㎸/㎝. The FE-SEM observations showed that the silica gel and poly(lactic-co-glycolic)acid fibers were mixed together completely and its handling property was much improved compared to that of the non-woven silica gel fabric. After soaking in the SBF for 1 week, low crystalline apatite crystals were also observed to occur on the silica fiber surfaces first and then they were also observed to occur on the poly(lactic-co-glycolic)acid fiber surfaces. From the results, it can be concluded that the poly(lactic-co-glycolic)acid and silica gel fibers mixed non-woven fabric made by electro-spinning method has a bioactivity. It means it has a potential to be used as a bone grafting material because of its apatite-forming ability, high surface area to volume ratio and high porosity.

• Periodical: Key Engineering Materials (Volumes 361-363)
• Pages: 519-522
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.361-363.519
• Online since: November 2007
• Authors: Yang Jo Seol, In Ae Kim, Yong Keun Lee, Bum Soon Lim, Sang Hoon Rhee
• Keywords: Apatite, Electro-Spinning, Non-Woven Fabric, Poly(lactic-Co-Glycolic Acid), Silica

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