Reconstruction of Cranial Bone Defects Using a Compound of Bone Marrow Stromal Cells and Hydroxyapatite-Tricalcium Phosphate

Lei Liu; Run Liang Chen; Yun Feng Lin; Wei Dong Tian; Sheng Wei Li

doi:10.4028/www.scientific.net/KEM.368-372.1235

Paper Titles

Preparation of ZrO_2(f)/PMMA-PMA Composites by a Suspension Polymerization Process
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Preparation of Porous Polycaprolactone Scaffolds by Using Freeze-Drying Combined Porogen-Leaching Methods
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Effect of Carbonate on the Properties of Bone Cement Containing PCCP and DCPA
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Improved Principal Component Analysis on the Comprehensive Hemocompatibility Evaluation of Biomaterials
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Reconstruction of Cranial Bone Defects Using a Compound of Bone Marrow Stromal Cells and Hydroxyapatite-Tricalcium Phosphate
p.1235

Preparation of Hydroxyapatite Coatings on Carbon/Carbon Composites by a Hydrothermal Electrodeposition Process
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Residual Stress and Reliability of Glass/Alumina Dental Bi-Layer Ceramics
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Effect of Multiple Firing on Wear Behavior of Dental Veneering Ceramic
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Strength and Fracture Mode for Dental Colored ZrO₂ Ceramics Coated with Dental Porcelain
p.1248

HomeKey Engineering MaterialsKey Engineering Materials Vols. 368-372Reconstruction of Cranial Bone Defects Using a...

Reconstruction of Cranial Bone Defects Using a Compound of Bone Marrow Stromal Cells and Hydroxyapatite-Tricalcium Phosphate

Abstract:

Hydroxyapatite-tricalcium phosphate (HA-TCP) is a new kind of material which shows good biocompatibility, biological degradability, and porosity. This study aimed to determine the effectiveness of HA-TCP as a bone tissue engineering scaffold. In this study, critical size cranial defects were reconstructed with compounds of autogenous bone marrow stromal cells (BMSCs) and HA-TCP. The resulting grafts were examined by X-ray, histological examination, semi-quantitative analysis of osteogenesis, immunochemical examination (collagen type I and III), scanning electron microscopy and transmission electron microscopy. The results showed that HA-TCP is a good bone tissue engineering scaffold and BMSCs/HA-TCP is a promising technique for reconstruction of bone defects.

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Periodical:

Key Engineering Materials (Volumes 368-372)

Pages:

1235-1237

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.368-372.1235

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Online since:

February 2008

Authors:

Lei Liu, Run Liang Chen, Yun Feng Lin, Wei Dong Tian, Sheng Wei Li

Keywords:

Bone Marrow Stromal Cell, Hydroxyapatite/Tricalcium Phosphate, Tissue Engineering

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