Biocompatibility Properties of ZrO2 Ceramics and ZrO2-TiN Composites
In order to study bicompability properties of fully dense ZrO2 ceramics containing 2-3 mol% Y2O3 stabilizer, and ZrO2-TiN composites containing 1-1.75 mol Y2O3 and 1 mol% Nd2O3 stabilizers, and electrical conductive TiN particles (40-60 vol%), cell viability was evaluated based on the reduction of tetrazolium salt to formazan crystals by living cells, the alkaline phosphatase production was investigated, and nitrite quantification was done for indirect evaluation of osteoblast NO production. The samples were defined biocompatible since there is not any significant change observed in the physiological functions of the cells when incubated together.
Marcelo Prado and Cecília Zavaglia
M. Arin et al., "Biocompatibility Properties of ZrO2 Ceramics and ZrO2-TiN Composites ", Key Engineering Materials, Vols. 396-398, pp. 51-54, 2009