Anti-fatigue design is a key content in product lifecycle management and there are many factors to affect the fatigue life of parts. For designing the fatigue life of shaft with a circumferential notch exactly, the influencing factors have been analyzed completely. The mechanics model for assessing the fatigue life of shaft is set up. The assessment method of fatigue life for shaft is set up according to the traditional fatigue life estimation. The effect of wearing parameter to fatigue life is analyzed and the results show that the wear is an important factor to affect the fatigue life.