Functionalized Calcium Phosphate Nanoparticles for Biomedical Application

Abstract:

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Calcium phosphate is a natural biomineral and therefore possesses an excellent biocompatibility due to its chemical similarity to human hard tissue (bone and teeth). Calcium phosphate nanoparticles can be precipitated under controlled conditions and used as carrier in biological systems, e.g. to transfer nucleic acids or drugs. Such nanoparticles can also be suitably functionalized with fluorescing dyes, polymeric agents, pro-drugs or activators. The small monodisperse nanoparticles only mildly influence the intracellular calcium level and therefore are not toxic for cells.

Info:

Periodical:

Edited by:

M. Vallet-Regí and M. Vila

Pages:

299-305

DOI:

10.4028/www.scientific.net/KEM.441.299

Citation:

M. Epple and A. Kovtun, "Functionalized Calcium Phosphate Nanoparticles for Biomedical Application", Key Engineering Materials, Vol. 441, pp. 299-305, 2010

Online since:

June 2010

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