With the rapid development of manufacturing technology, high speed, high efficiency and high performance have been the characteristics of metal cutting. And cutting technology has been faced with a lot of opportunities and challenges. But at the same time, cutting parameter optimization has gradually been one of the most outstanding bottle-necks that restrict the rapid enhancement of cutting technology. Since the essences of cutting process, such as cutting force and temperature, are invariable, force and heat constraint are performed here to optimize milling parameters of titanium alloy. Influences of cutting edge strength and cutting temperature on milling parameters are analyzed. Finally, feasible region of milling parameters are obtained.