In order to control a large number of microbubbles with a pumping ultrasonic wave, it is essential to consider a bubble-to-bubble interaction. This paper proposes a simplified microbubble dynamics simulation method considered with bubble-to-bubble interaction in ultrasonic wave field. The microbubble dynamics is solved with difference method based on the Stokes’s low and the secondary Bjerknes force between microbubbles. The laminar flow is considered in the cylindrical calculation region. The effectiveness of the frequency sweep method in laminar flow is shown with simulation results. And a usefulness of this dynamics simulation is also discussed through the experimental result.