Volatile organic compounds (VOCs) are main type of indoor pollutants which are found in many workstation materials. In multi-layer work surface panels, different VOCs have different chemical and physical properties which will affect their transport properties and storage properties. Therefore, the VOC emission process and emission rate are generally different and depend on the type of VOCs. The effect of the initial condition, such as temperature, relative humidity, air change rate, initial VOC concentration and pollutant type are evaluated separately. This paper uses a build environment simulation (BES) program to investigate the effect of these factors on the VOC concentration in the air. Based on the theoretic analysis, several means can be adopted to reduce the pollutant emission and improve the indoor air quality (IAQ).