Optimal Design of Microneedles Inserts into Skin by Numerical Simulation

Chui Yu Chiu; Hsin Chuan Kuo; Yi Lin; Jeou Long Lee; Yung Kang Shen; Sheng Jie Kang

doi:10.4028/www.scientific.net/KEM.516.624

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Research on Unbalance Signal Extraction under the Constraints of Low Operation Speed and Limited Acquisition Time
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Optimal Design of Microneedles Inserts into Skin by Numerical Simulation
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HomeKey Engineering MaterialsKey Engineering Materials Vol. 516Optimal Design of Microneedles Inserts into Skin...

Optimal Design of Microneedles Inserts into Skin by Numerical Simulation

Abstract:

The purpose of this research is to find the optimal design for biodegradable polymer microneedle patches. Based on the mechanical properties of different skin layers and the failure criterion of the material, this research designs a microneedle of four types and three sizes, then discusses the insertion force and the variation of stress during the process of PLA microneedle insertion into skin by numerical simulation. This research uses the dynamic finite element software ANSYS / LS-DYNA to simulate the processing for PLA microneedle inserts into skin. The master microneedle array was fabricated by the MEMS process. This research uses PDMS to fabricate the mould for microneedles. Finally, a biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated using a PDMS mould micro hot embossing method.

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Proceedings of Precision Engineering and Nanotechnology

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Periodical:

Key Engineering Materials (Volume 516)

Pages:

624-628

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.516.624

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Online since:

June 2012

Authors:

Chui Yu Chiu, Hsin Chuan Kuo, Yi Lin, Jeou Long Lee, Yung Kang Shen, Sheng Jie Kang

Keywords:

Numerical Simulation, Optimal Design, PLA Microneedle

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References

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