Characterization of α/β-TCP Based Injectable Calcium Phosphate Cement as a Potential Bone Substitute

Kemal Sariibrahimoglu; Joop G.C. Wolke; Sander C.G. Leeuwenburgh; John A. Jansen

doi:10.4028/www.scientific.net/KEM.529-530.157

Paper Titles

3-D Printed Bioactive Bone Replacement Scaffolds of Alkaline Substituted Ortho-Phosphates Containing Meta- and Di-Phosphates
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Fabrication of Three Different Types of Porous Carbonate-Substituted Apatite Ceramics for Artificial Bone
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Evaluating Initial Content of the Slurry and Cooling Rate on the Microstructural and Mechanical Characteristics of Freeze Casted Hydroxyapatite Macroporous Scaffolds
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Fabrication of Calcite Foam by Inverse Ceramic Foam Method
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Characterization of α/β-TCP Based Injectable Calcium Phosphate Cement as a Potential Bone Substitute
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Adsorption Behavior of Sodium Inositol Hexaphosphate on the Surface of Hydroxyapatite
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Comparative Study on Bioresorbability of Chelate-Setting Cements with Various Calcium-Phosphate Phase Using Rabbit Model
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In Vitro Biological Evaluation of Anti-Tumor Effect of the Chelate-Setting Hydroxyapatite Cement
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Studies on the Anti-Tumor Action of Chelate-Setting Apatite Cements
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HomeKey Engineering MaterialsKey Engineering Materials Vols. 529-530Characterization of α/β-TCP Based Injectable...

Characterization of α/β-TCP Based Injectable Calcium Phosphate Cement as a Potential Bone Substitute

Abstract:

Calcium phosphate cements (CPCs) can be a suitable scaffold material for bone tissue engineering because of their osteoconductivity and perfect fit with the surrounding tissue when injected in situ. However, the main disadvantage of hydroxyapatite (HA) forming CPC is its slow degradation rate, which hinders complete bone regeneration. A new approach is to use hydraulic apatite cement with mainly α/β-tricalciumphosphate (TCP) instead of α-TCP. After hydrolysis the α/β-TCP transforms in a partially non-absorbable HA and a completely resorbable β-TCP phase. Therefore, α-TCP material was thermally treated at several temperatures and times resulting in different α/β-TCP ratios. In this experiment, we developed and evaluated injectable biphasic calcium phosphate cements (BCPC) in vitro. Biphasic α/β-TCP powder was produced by heating α-TCP ranging from 1000-11250°C. Setting time and compressive strength of the CPCs were analyzed after soaking in PBS for 6 weeks. Results demonstrated that the phase composition can be controlled by the sintering temperature. Heat treatment of α-TCP, resulted in 100%, 75% and 25% of α-to β-TCP transformation, respectively. Incorporation of these sintered BCP powder into the cement formulation increased the setting time of the CPC paste. Compressive strength decreased with increasing β-TCP content. In this study, biphasic CPCs were produced and characterized in vitro. This injectable biphasic CPC presented comparable properties to an apatitic CPC.

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Key Engineering Materials (Volumes 529-530)

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157-160

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https://doi.org/10.4028/www.scientific.net/KEM.529-530.157

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November 2012

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Kemal Sariibrahimoglu, Joop G.C. Wolke, Sander C.G. Leeuwenburgh, John A. Jansen

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Biphasic, Calcium Phosphate Cement

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